SERUM-LIPID AND LIPOPROTEIN PROFILES IN CHILDHOOD
SERUM-LIPID AND LIPOPROTEIN PROFILES IN CHILDHOOD
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DOI：
10.1016/0091-7435(83)90168-8
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发表时间：
1983-01-01
影响因子：
5.1
通讯作者：
MANCINI, M
中科院分区：
文献类型：
--
作者：
FARINARO, E;GIUMETTI, D;MANCINI, M
血清脂质和脂蛋白以及其他因素已被证明可以预测成年人群未来有症状的冠心病。有许多关于不同人群成人血脂的流行病学数据；儿童中的类似数据表明，不同人群之间甚至同一人群的个体之间存在很大的地理差异，这表明遗传和环境因素都是血清脂质浓度的决定因素。出生时和儿童期的血清胆固醇主要由低密度脂蛋白（LDL）和高密度脂蛋白（HDL）携带，而极低密度脂蛋白（VLDL）在同一时期仍然非常低。纵向研究表明，男孩的血清胆固醇水平随着年龄的增长略有下降，但女孩则没有；下降趋势在 10 岁至 14 岁之间最为明显。低密度脂蛋白胆固醇也遵循同样的趋势。随着年龄的增长，血清总甘油三酯和极低密度脂蛋白甘油三酯持续轻微增加。高密度脂蛋白胆固醇似乎保持恒定水平，仅随着年龄的增长而略有变化。此外，低密度脂蛋白胆固醇与未来的水平具有很大的一致性。对儿童进行的测量证实，幼儿时期可能存在高胆固醇水平，这表明需要对年轻人进行后续研究，以评估儿童时期的高胆固醇血症是否可以预测未来的冠状动脉事件。
Serum lipids and lipoproteins as well as other factors have been shown to be predictive of future symptomatic coronary heart disease in adult populations. Many epidemiologic data are available on serum lipids in adults in different populations; similar data in children indicate a large geographic variability between different populations and even among individiuals of the same population, suggesting that both genetic and environmental factors are determinants of serum lipid concentrations. Serum cholesterol at birth and during childhood is carried predominantly by low-density lipoprotein (LDL) and high-density lipoprotein (HDL) whereas very low-density lipoprotein (VLDL) remains very low during the same period. Longitudinal studies show that serum cholesterol level decreases slightly with age in boys but not in girls; the decreasing trend is most evident between 10 and 14 years of age. LDL cholesterol follows the same trend. A continuous slight increase in serum total and VLDL triglyceride has been shown with age. HDL cholesterol seems to maintain a constant level with only slight variation with age. Moreover, LDL cholesterol has great consistency with future levels. Measurements made in children confirm that high levels of cholesterol may be present at early ages, suggesting the need for follow-up studies in young populations in order to evaluate whether hypercholesterolemia in childhood is predictive of future coronary events.