Influence of radical prostatectomy for prostate cancer on work status and working life 3 years after surgery
Influence of radical prostatectomy for prostate cancer on work status and working life 3 years after surgery
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DOI：
10.1007/s11764-014-0399-6
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发表时间：
2015-06-01
影响因子：
3.7
通讯作者：
Fossa, Sophie Dorothea
中科院分区：
文献类型：
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作者：
Dahl, Sigrun;Loge, Jon Havard;Fossa, Sophie Dorothea
为探讨前列腺癌根治术(RP)对男性术后3年工作状态和工作年限的影响，对330例前列腺癌(PCa)患者行根治性前列腺癌根治术后3年的工作状况进行了前瞻性问卷调查。我们将他们的术后工作状态分为“不变或增加”和“减少”。参与者还报告了他们的工作生活是否在一定程度上受到了PCA轨迹的影响，或者在很大程度上受到了影响。以社会人口学和临床特征为自变量，以工作状态或PCA轨迹对工作生活的影响为因变量，建立了单因素和多因素Logistic回归模型，25%的研究对象已经退休。在剩下的参与者中，大约20%的人工作状态降低，在多变量分析中，这与年龄的增加显著相关。在仍活跃在职场的男性中，有三分之一认为PCA对他们的工作生活产生了负面影响。尽管RP不影响大多数男性的工作状态，但他们中约三分之一的人会因为RP和/或RP后附加抗癌治疗的不良反应而在工作生活中遇到问题。大多数PCA幸存者有望在RP后继续工作至少3年，但对一些人来说，RP和/或附加抗癌治疗后持续的不良反应会对他们的工作生活产生负面影响。对工作中的男性进行RP之前的咨询应该包括RP后可能发生的关于工作状态和工作生活的变化。
The purpose of this study is to study the influence of radical prostatectomy (RP) for prostate cancer on work status and working life in men 3 years after surgery.In a prospective, questionnaire-based study on adverse effects after RP, 330 prostate cancer (PCa) patients who had been active in the workforce before RP described their work status 3 years after having surgery. We dichotomized their postoperative work status into "unchanged or increased" versus "reduced." The participants also reported whether their working life was influenced by the PCa trajectory to no, some, or a great extent. Univariate and multiple logistic regression models were established with sociodemographic and clinical characteristics as independent variables and "work status" or "influence of PCa trajectory on working life" as dependent variables.Twenty-five percent of the participants had retired. Of the remaining participants, approximately 20 % had a reduced work status, which in the multivariate analyses was significantly associated with increasing age. One third of the men still active in the workforce considered the PCa to negatively influence their working life. This was independently associated with bother related to urinary leakage, fatigue, and having undergone additional oncological therapy (pelvic radiotherapy and/or hormone treatment).Though RP does not affect work status in most men, approximately one third of them experience problems in their working life due to adverse effects related to RP and/or additional post-RP anti-cancer therapy.Most PCa survivors can expect to remain in the workforce for at least 3 years after RP, but for some, persistent adverse effects after RP and /or additional anti-cancer treatment negatively affect their working life. Pre-RP counseling of men within the workforce should cover possible post-RP changes concerning work status and working life.