OLFACTORY DYSFUNCTION IN PARKINSONISM - A GENERAL DEFICIT UNRELATED TO NEUROLOGIC SIGNS, DISEASE STAGE, OR DISEASE DURATION
OLFACTORY DYSFUNCTION IN PARKINSONISM - A GENERAL DEFICIT UNRELATED TO NEUROLOGIC SIGNS, DISEASE STAGE, OR DISEASE DURATION
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DOI：
10.1212/wnl.38.8.1237
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发表时间：
1988-08-01
期刊：
影响因子：
9.9
通讯作者：
STELLAR, S
中科院分区：
文献类型：
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作者：
DOTY, RL;DEEMS, DA;STELLAR, S
为了探索帕金森病（PD）相关嗅觉功能障碍的性质，81名在认知筛查测试中得分良好的PD患者接受了宾夕法尼亚大学40气味识别测试; 38名患者另外接受了强制选择的苯乙醇气味检测阈值测试。11个神经系统的临床评级范围为5至39个月。相对于匹配的对照组，PD患者在两种类型的嗅觉测试中表现出一致且显著的下降（ps < 0.0001）。气味识别赤字不限于任何子集的气味，并没有证据纵向变化。因素分析的变量之间的相互关系产生了六个容易解释的因素：一般运动，口腔运动，嗅觉功能，认知功能，震颤，和性别。嗅觉测试分数是独立的所有其他措施，包括疾病的阶段和持续时间。72%的PD患者在测试前不知道嗅觉障碍;那些知道的人的测试分数明显较低。PD患者的嗅觉测试分数与阿尔茨海默病患者的嗅觉测试分数的统计比较发现，这些疾病的嗅觉障碍是无法区分的。这些数据支持这一假设，即PD的嗅觉缺陷是一个普遍的和稳定的，可能发生在疾病过程的早期。
To explore the nature of the olfactory dysfunction associated with Parkinson''s disease (PD), 81 PD patients who scored well on a cognitive screening test were administered the 40-odorant University of Pennsylvania Smell Identification Test; 38 were additionally given a forced-choice phenylethyl alcohol odor detection threshold test. Clinical ratings of 11 neurologic ranging from 5 to 39 months. Relative to matched controls, the PD patients exhibited consistent and marked decrements on both types of olfactory tests (ps < 0.0001). The odor identification deficit was not restricted to any subset of odorants and did not evidence longitudinal change. A factor analysis of the intercorrelations among the variables yielded six easily interpretable factors: general motor, oral motor, olfactory function, cognitive function, tremor, and gender. Olfactory test scores were independent of all other measures, including disease stage and duration. Seventy-two percent of the PD patients were unaware of a smell disorder before testing; those who were aware had significantly lower test scoresl A statistical comparison of PD patients'' olfactory test scores to those obtained from Alzheimer''s disease patients found the olfactory disorders of these diseases to be indistinguishable. The data support the hypothesis that the olfactory deficit of PD is a general and stable one which likely occurs early in the disease process.