Fast removal of the antibiotic flumequine from aqueous solution by ozonation: Influencing factors, reaction pathways, and toxicity evaluation
Fast removal of the antibiotic flumequine from aqueous solution by ozonation: Influencing factors, reaction pathways, and toxicity evaluation
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臭氧氧化快速去除水溶液中抗生素氟甲喹：影响因素、反应途径和毒性评价
DOI：
10.1016/j.scitotenv.2015.09.048
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发表时间：
2016-01-15
影响因子：
9.8
通讯作者：
Wang, Zunyao
中科院分区：
文献类型：
--
作者：
Feng, Mingbao;Yan, Liqing;Wang, Zunyao
氟喹诺酮(Flumequine，Flu)作为第一代氟喹诺酮类抗生素，在地表水和城市污水中普遍存在。鉴于流感可能对水生物种造成的不利影响，这种抗生素的移除受到了全世界的关注。在本研究中，系统地确定了臭氧氧化过程中流感的动力学、转化产物、机理和毒性变化。从降解动力学的角度研究了溶液pH值、无机离子投加量、溶解有机物和叔丁醇(自由基清除剂)以及水基质类型对臭氧氧化去除流感的可能影响。获得的数据表明，臭氧可以作为一种有效的氧化剂，从天然水中快速去除流感。采用液-质联用技术对臭氧氧化过程中流感的13种转化产物进行了鉴定，并对其具体反应机理进行了探讨。初步提出了包括羟基化、脱羧基和脱氟基在内的降解途径。同时，还观察到了三种低分子量羧酸的生成。此外，还对臭氧转化流感混合物的潜在毒性进行了评价。总体而言，本论文可以为系统阐明这种抗生素在水中的臭氧氧化过程做出独特的贡献。(C)2015爱思唯尔B.V.保留所有权利。
As one of the first generation of fluoroquinolone antibiotics, flumequine (FLU) has been detected ubiquitously in surface waters and municipal waste waters. In light of FLU's possible adverse effects on aquatic species, the removal of this antibiotic has received worldwide attention. In this study, the kinetics, transformation products, mechanisms and toxicity variations of the ozonation process for FLU were systematically determined. The possible effects of solution pH, addition of inorganic ions, dissolved organic matter, and tert-butyl-alcohol (a radical scavenger), as well as the type of water matrices on FLU removal by ozonation, were studied from the perspective of the degradation kinetics. The data obtained suggested that ozone can be used as an effective oxidant for the fast removal of FLU from natural waters. Using liquid chromatography-mass spectrometry, a total of thirteen transformation products of FLU during ozonation were identified, and their specific reaction mechanisms were also proposed. The degradation pathways involving the hydroxylation, decarboxylation and defluorination were tentatively proposed. Meanwhile, the generation of three low-molecular-weight carboxylic acids was also observed. In addition, the potential toxicity of the transformation mixtures of FLU by ozone was evaluated. Overall, this paper can be a unique contribution to the systematic elucidation of the ozonation process of this antibiotic in water. (C) 2015 Elsevier B.V. All rights reserved.