Hematology and Inflammatory Signaling of Intracerebral Hemorrhage
Hematology and Inflammatory Signaling of Intracerebral Hemorrhage
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DOI：
10.1161/strokeaha.111.000662
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发表时间：
2013-06-01
期刊：
影响因子：
8.3
通讯作者：
Ziai, Wendy C.
中科院分区：
文献类型：
--
作者：
Ziai, Wendy C.
Thrombin is an essential component of the coagulation cascade and forms immediately after ICH, but is also formed because of prothrombin influx, resulting from ICH–induced blood–brain barrier disruption, which begins to occur several hours after ICH and results in a delayed thrombin generation. 1 Activation of the extrinsinc or intrinsic coagulation cascade results in production of factor Xa, which cleaves prothrombin to thrombin; thrombin then cleaves fibrinogen to fibrin
