AN EXAMINATION OF RESEARCH DESIGN EFFECTS ON THE ASSOCIATION OF TESTOSTERONE AND MALE AGING - RESULTS OF A METAANALYSIS
AN EXAMINATION OF RESEARCH DESIGN EFFECTS ON THE ASSOCIATION OF TESTOSTERONE AND MALE AGING - RESULTS OF A METAANALYSIS
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DOI：
10.1016/0895-4356(91)90028-8
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发表时间：
1991-01-01
影响因子：
7.2
通讯作者：
LONGCOPE, C
中科院分区：
文献类型：
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作者：
GRAY, A;BERLIN, JA;LONGCOPE, C
睾酮的研究可能会在未来内分泌功能的流行病学工作和年龄相关疾病的临床治疗中占据重要地位。因此，了解正常男性衰老过程中涉及的荷尔蒙变化至关重要。作者利用荟萃分析技术，检查了 88 项已发表的关于男性年龄与睾酮关系的研究。这些研究报告了相互矛盾的结果：年龄与睾酮的相关性范围为 -0.68 至 +0.68。在交叉研究比较中，某些研究设计特征（例如血液采样的时间）和各种样本特征（例如志愿者与作为受试者的患者）与平均睾酮水平和年龄-睾酮关系的斜率相关。例如，对于不排除患病男性的受试者亚组，平均睾酮水平较低，并且不会随着年龄的增长而下降。相比之下，仅包括健康受试者的亚组总体睾酮水平较高，并且随着年龄的增长睾酮水平下降。将讨论这些结果对未来流行病学研究的设计、分析和报告的影响。这些结果也说明了荟萃分析在老年人研究中的实用性。
The study of testosterone is likely to be prominent in future epidemiological work on endocrine function and the clinical treatment of age-related diseases. Thus, understanding the hormonal changes involved in the normal male aging process will be critical. Using techniques of meta-analysis, the authors examined 88 published studies of the age-testosterone relation in men. These studies reported conflicting results: age-testosterone correlations ranged from -0.68 to +0.68. In cross-study comparisons, certain research design characteristics (e.g. time of day of blood sampling) and various sample characteristics (e.g. volunteers vs patients as subjects) were related to both mean testosterone level and the slope of the age-testosterone relation. For example, for subgroups of subjects that did not exclude ill men, the mean testosterone levels were low, and did not decline with age. Subgroups that included only healthy subjects, in contrast, had higher overall testosterone levels and showed a decline of testosterone with age. Implications of these results for design, analysis and reporting of future epidemiologic studies will be discussed. These results also illustrate the utility of meta-analysis for research with the aged.