Visceral adiposity is significantly associated with type 2 diabetes in middle-aged and elderly Chinese women: A cross-sectional study
Visceral adiposity is significantly associated with type 2 diabetes in middle-aged and elderly Chinese women: A cross-sectional study
复制标题
内脏肥胖与中国中老年女性2型糖尿病显着相关：一项横断面研究
DOI：
10.1111/1753-0407.12499
复制
发表时间：
2017-10-01
影响因子：
4.5
通讯作者：
Ning, Guang
中科院分区：
文献类型：
--
作者：
Lv, Xiaofei;Zhou, Weiwei;Ning, Guang
背景研究表明，内脏脂肪与2型糖尿病（T2 D）相关，与体重指数（BMI）无关。然而，关于内脏脂肪与T2 D之间关系的流行病学数据在中国人中很少见。本研究的目的是探讨内脏脂肪面积（VFA）是否与T2 D超出和以上的BMI在中国population.MethodsThe本社区为基础的横断面研究进行了4126人（2545名女性，1581名男性）年龄40岁，T2 D诊断根据1999年世界卫生组织的标准。VFA测量脂肪面积分析仪使用bioelectrical impedance analysis.ResultsParticipants分为正常体重和超重/肥胖组根据BMI。在每组中，与VFA低于中位数的女性相比，VFA高于中位数的女性患糖尿病的风险显著增加（正常体重组OR为1.88，95%可信区间CI为1.31-2.69; OR 2.10，超重/肥胖组的95%CI 1.54-2.85），而在男性中，两组的相应关联均不显着。在女性中，在多变量调整（包括BMI）后，VFA每增加一个标准差，患T2 D的风险就增加45%（OR 1.45，95% CI 1.26-1.67），而在男性中，BMI（而非VFA）与T2 D独立相关（OR 1.18，95%CI 1.02-1.37）。结论内脏脂肪与女性T2 D独立相关，无论肥胖状态如何，而在男性中，BMI可能比内脏脂肪对T2 D有更重要的影响。
BackgroundPrevious studies suggest that visceral fat is associated with type 2 diabetes (T2D) independent of body mass index (BMI). However, epidemiological data about the relationship between visceral fat and T2D are rare in Chinese. The aim of the present study was to investigate whether visceral fat area (VFA) is associated with T2D beyond and above BMI in the Chinese population.MethodsThe present community-based cross-sectional study was conducted in 2013 on 4126 individuals (2545 women, 1581 men) aged 40years, with T2D diagnosed according to 1999 World Health Organization criteria. The VFA was measured by a fat area analyzer using bioelectrical impedance analysis.ResultsParticipants were categorized into normal weight and overweight/obese groups according to BMI. Within each group, compared with women with below-median VFA, women with above-median VFA had a significantly increased risk of diabetes (odds ratio [OR] 1.88, 95% confidence interval [CI] 1.31-2.69 in the normal weight group; OR 2.10, 95% CI 1.54-2.85 in the overweight/obese group), whereas among men the corresponding associations were not significant in either group. Among women, after multivariable adjustment including BMI, each one standard deviation increase in VFA was significantly associated with a 45% higher risk of having T2D (OR 1.45, 95% CI 1.26-1.67), whereas among men BMI, not VFA, was independently associated with T2D (OR 1.18, 95% CI 1.02-1.37).ConclusionsVisceral fat was independently associated with T2D in women regardless of obesity status, whereas in men BMI may have a more important effect on T2D than visceral fat.