Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells.
Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells.
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DOI：
10.1016/j.xcrm.2021.100354
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发表时间：
2021-07-20
期刊：
影响因子：
--
通讯作者：
McElrath MJ
中科院分区：
文献类型：
--
作者：
Cohen KW;Linderman SL;Moodie Z;Czartoski J;Lai L;Mantus G;Norwood C;Nyhoff LE;Edara VV;Floyd K;De Rosa SC;Ahmed H;Whaley R;Patel SN;Prigmore B;Lemos MP;Davis CW;Furth S;O'Keefe JB;Gharpure MP;Gunisetty S;Stephens K;Antia R;Zarnitsyna VI;Stephens DS;Edupuganti S;Rouphael N;Anderson EJ;Mehta AK;Wrammert J;Suthar MS;Ahmed R;McElrath MJ
结束 COVID-19 大流行需要对 SARS-CoV-2 具有长期免疫力。在这里，我们对 254 名 COVID-19 患者进行了长达 8 个月的纵向评估，并发现了持久的广泛免疫反应。 SARS-CoV-2 刺突结合和中和抗体表现出双相衰减，半衰期延长至 >200 天，表明产生了寿命更长的浆细胞。 SARS-CoV-2 感染还会提高 SARS-CoV-1 和常见 β 冠状病毒的抗体滴度。此外，刺突特异性 IgG+ 记忆 B 细胞持续存在，这预示着在病毒再次暴露或接种疫苗后会出现快速抗体反应。病毒特异性 CD4+ 和 CD8+ T 细胞具有多功能性，估计半衰期为 200 天。有趣的是，CD4+ T 细胞反应同样针对多种 SARS-CoV-2 蛋白，而 CD8+ T 细胞反应则优先针对核蛋白，这凸显了在未来疫苗中包含核蛋白的潜在重要性。综上所述，这些结果表明，广泛而有效的免疫力可能在康复的 COVID-19 患者中长期持续存在。大多数康复的 COVID-19 患者在感染后会产生广泛、持久的免疫力 中和抗体显示双相衰减，半衰期 >200 天 尖峰 IgG+ 记忆 B 细胞在感染后增加并持续存在 耐用的多功能 CD4 和 CD8 T 细胞识别不同的病毒表位区域 Cohen 等人。在 8 个月内纵向评估 254 名 COVID-19 患者的免疫反应。 SARS-CoV-2 特异性结合和中和抗体表现出双相衰减，表明浆细胞的生成寿命较长。记忆B细胞保持稳定； CD4 和 CD8 记忆 T 细胞具有多功能性。因此，广泛而有效的免疫力可能会在 COVID-19 后长期持续存在。
Ending the COVID-19 pandemic will require long-lived immunity to SARS-CoV-2. Here, we evaluate 254 COVID-19 patients longitudinally up to 8 months and find durable broad-based immune responses. SARS-CoV-2 spike binding and neutralizing antibodies exhibit a bi-phasic decay with an extended half-life of >200 days suggesting the generation of longer-lived plasma cells. SARS-CoV-2 infection also boosts antibody titers to SARS-CoV-1 and common betacoronaviruses. In addition, spike-specific IgG+ memory B cells persist, which bodes well for a rapid antibody response upon virus re-exposure or vaccination. Virus-specific CD4+ and CD8+ T cells are polyfunctional and maintained with an estimated half-life of 200 days. Interestingly, CD4+ T cell responses equally target several SARS-CoV-2 proteins, whereas the CD8+ T cell responses preferentially target the nucleoprotein, highlighting the potential importance of including the nucleoprotein in future vaccines. Taken together, these results suggest that broad and effective immunity may persist long-term in recovered COVID-19 patients. Most recovered COVID-19 patients mount broad, durable immunity after infection Neutralizing antibodies show a bi-phasic decay with half-lives >200 days Spike IgG+ memory B cells increase and persist post-infection Durable polyfunctional CD4 and CD8 T cells recognize distinct viral epitope regions Cohen et al. evaluate immune responses longitudinally in 254 COVID-19 patients over 8 months. SARS-CoV-2-specific binding and neutralizing antibodies exhibit biphasic decay, suggesting long-lived plasma cell generation. Memory B cells remain stable; CD4 and CD8 memory T cells are polyfunctional. Thus, broad and effective immunity may persist long-term following COVID-19.
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影响因子：
64.5
作者：
Sette A;Crotty S
通讯作者：
Crotty S
影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
2.1
作者：
Newton, MA;Noueiry, A;Ahlquist, P
通讯作者：
Ahlquist, P
影响因子：
2.1
作者：
Finak, Greg;McDavid, Andrew;Gottardo, Raphael
通讯作者：
Gottardo, Raphael
影响因子：
56.9
作者：
Hsieh, Ching-Lin;Goldsmith, Jory A.;McLellan, Jason S.
通讯作者：
McLellan, Jason S.