Alterations of Photopic Negative Response of Multifocal Electroretinogram in Patients with Glaucoma
Alterations of Photopic Negative Response of Multifocal Electroretinogram in Patients with Glaucoma
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DOI：
10.3109/02713683.2014.915575
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发表时间：
2015-01-01
影响因子：
2
通讯作者：
Kurosaka, Daijiro
中科院分区：
文献类型：
--
作者：
Kaneko, Muneyoshi;Machida, Shigeki;Kurosaka, Daijiro
目的：目的：探讨青光眼对低频刺激诱发的多焦视网膜电图（mfERG）的影响。刺激频率为6.25 Hz，刺激是以中央凹（中心）为中心的半径为6.8度的圆。MfERG也由放置在黄斑周围的四分之一环（上级/颞部;下级/颞部;上级/鼻部;和下级/鼻部象限）引起。环内缘半径为6.8 °，外缘半径为20 °。通过标准自动视野检查确定实际灵敏度。结果：mfERG由负波（N1）、正波（P1）和慢负波（N2）组成。正常对照眼与青光眼眼各区域的N1和P1反应密度均无显著性差异。N2反应密度随青光眼严重程度的增加而显著降低。与对照值相比，即使在青光眼的早期阶段也有显著降低。在中心，N2响应密度与GCC厚度和平均灵敏度显著相关。然而，在其他刺激领域，有没有显着减少的任何组件的mfERGs.Conclusions：这些结果表明，N2组件的慢序列mfERGs是受青光眼在视网膜中央区域。当检查青光眼患者的mfERG时，应考虑视网膜神经节细胞活性对N2的贡献的区域差异。
Purpose: To determine the effect of glaucoma on the multifocal electroretinograms (ERGs) (mfERGs) elicited by low-frequency stimuli.Methods: Forty-four patients with open-angle glaucoma and 15 normal subjects were studied. The stimulus frequency was 6.25 Hz, and the stimulus was a circle with a 6.8 degrees radius that was centered on the fovea (center). MfERGs were also elicited by a quarter of an annulus placed around the macula (superior/temporal; inferior/temporal; superior/nasal; and inferior/nasal quadrants). The radius of the inner border of the annulus was 6.8 degrees and that of the outer border was 20 degrees. The actual sensitivity was determined by standard automated perimetry. The thickness of the ganglion cell complex (GCC) was measured by optical coherence tomography.Results: The mfERGs consisted of a negative wave (N1) followed by a positive wave (P1), and followed by a slow negative wave (N2). There were no significant differences in the response densities of N1 and P1 between the normal control and glaucomatous eyes in any areas. The N2 response density was significantly reduced with the severity of glaucoma in the center. There was a significant reduction even at an early stage of glaucoma compared to control values. In the center, the N2 response density was significantly correlated with the GCC thickness and mean sensitivity. However, in other stimulus areas, there was no significant reduction of any components of the mfERGs.Conclusions: These results suggest that the N2 component of the slow-sequence mfERGs is affected by glaucoma in the central retinal area. Regional variations in the contribution of the retinal ganglion cell activity to the N2 should be considered when examining the mfERGs in glaucoma patients.