The psychotic phenomenon in probable Alzheimer's disease: a positron emission tomography study.
The psychotic phenomenon in probable Alzheimer's disease: a positron emission tomography study.
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可能的阿尔茨海默病的精神病现象：正电子发射断层扫描研究。
DOI：
10.1176/jnp.13.1.50
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
DeKosky,ST
中科院分区：
文献类型：
--
作者：
Lopez,OL;Smith,G;Becker,JT;Meltzer,CC;DeKosky,ST
采用正电子发射断层扫描技术研究阿尔茨海默病(AD)患者精神症状的发生机制。对2例有妄想症和2例有幻觉的AD患者与5例无精神病史的AD患者进行比较。偏执型妄想症患者左侧背外侧前额叶和左侧内侧颞叶皮质的相对局部脑血流量(Rel-CBF)减少。有视觉幻觉的患者显示右侧顶叶、左侧内侧颞叶和左侧背外侧前额叶皮质的Rel-CBF减少。这些发现支持这样的假设，即额叶-颞叶异常与AD的偏执妄想有关。相比之下，视觉幻觉与顶叶以及额叶和颞叶功能障碍有关。在这些患者中，左侧前额叶-颞叶皮质功能障碍似乎是阿尔茨海默病精神病现象发展的共同特征。
Positron emission tomography was used to examine the mechanisms of the psychotic phenomenon in Alzheimer's disease (AD). Data from 2 patients with delusions and 2 with hallucinations were compared with those of 5 AD patients without psychosis. The patients with paranoid delusions had diminished relative regional cerebral blood flow (rel-CBF) in the left dorsolateral prefrontal and left medial temporal cortices. The patients with visual hallucinations showed diminished rel-CBF in the right parietal, left medial temporal, and left dorsolateral prefrontal cortices. These findings support the hypothesis that a frontal-temporal abnormality is associated with paranoid delusions in AD. By contrast, visual hallucinations are associated with parietal as well as frontal and temporal lobe dysfunction. In these patients, a left prefrontal–temporal cortex dysfunction appears to be a common denominator for the development of the psychotic phenomenon in AD.