Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.
Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.
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白介素10：肥大细胞及其祖细胞的新型刺激因子。
DOI：
10.1084/jem.173.2.507
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发表时间：
1991-02-01
影响因子：
15.3
通讯作者：
Rennick, D M
中科院分区：
文献类型：
--
作者：
Thompson-Snipes, L;Dhar, V;Bond, M W;Mosmann, T R;Moore, K W;Rennick, D M
我们已经表征了鼠细胞因子合成抑制因子（称为白细胞介素10（IL-10））的肥大细胞刺激活性。结果发现，单独的IL-10不能支持肥大细胞系和肥大细胞祖细胞的生长。然而，当与 IL-3 或 IL-4 结合时，它会显着促进它们的生长。此外，IL-4加IL-10支持肥大细胞以及IL-3的增殖，表明这两个因子可能为其发育提供一条独立于IL-3的途径。然而，IL-10、IL-4 和 IL-3 的组合可刺激肥大细胞的最佳生长。这组特定的细胞因子由活化的 T 细胞协调产生，可能构成在某些免疫反应期间调节肥大细胞发育早期和晚期的有效网络。
We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL- 10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth when combined with IL-3 or IL-4. Moreover, IL-4 plus IL-10 supported the proliferation of mast cells as well as IL-3, suggesting that these two factors may provide a pathway for their development independent of IL-3. However, optimal mast cell growth was stimulated by the combination of IL-10, IL-4, and IL-3. This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses.