Activation mapping in essential tremor with functional magnetic resonance imaging
Activation mapping in essential tremor with functional magnetic resonance imaging
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DOI：
10.1002/ana.410410108
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发表时间：
1997-01-01
影响因子：
11.2
通讯作者：
Oertel, WH
中科院分区：
文献类型：
--
作者：
Bucher, SF;Seelos, KC;Oertel, WH
我们使用功能性磁共振成像 (FMRI) 来研究 12 名原发性震颤 (ET) 患者、15 名对照受试者的模拟姿势性震颤以及两组被动腕关节摆动患者中与单侧姿势性震颤相关的可能的大脑激活模式。在特发性震颤期间，患者主要表现出初级运动和第一感觉区、苍白球和丘脑的对侧激活，但齿状核、小脑半球和红核的双侧激活。只有 2 名患者靠近橄榄核的髓质有活动。 ET 患者的单侧被动手腕摆动仅导致小脑、齿状核和红核的单侧激活。与 ET 患者的不自主震颤状况相反，对照受试者的模拟震颤状况与小脑、齿状核或红核的双侧活动无关。与对照组的模拟震颤相比，ET 患者的不自主震颤与小脑半球和红核的激活程度显着更大相关（p < 0.003）。我们的 FMRI 研究表明 ET 主要与附加相关。小脑、红核和苍白球的对侧小脑通路激活和过度活动，但没有明显的内在橄榄激活。
We used functional magnetic resonance imaging (FMRI) to study possible cerebral activation patterns associated with unilateral postural tremor in 12 patients with essential tremor (ET), with mimicked postural tremor in 15 control subjects, and with passive wrist oscillation in both groups. During essential tremor, patients showed mainly contralateral activation of the primary motor and primacy sensory areas, the globus pallidus, and the thalamus, but bilateral activation of the nucleus dentatus, the cerebellar hemispheres, and the red nucleus. Only 2 patients presented with activity in the medulla close to the olivary nucleus. Unilateral passive wrist oscillation of ET patients resulted in only unilateral activation of the cerebellum, nuclei dentati, and red nuclei. In contrast to the involuntary tremor condition of ET patients, the mimicked tremor condition of the control subjects was not associated with bilateral activity in the cerebellum, nuclei dentati, or red nuclei. Involuntary tremor of ET patients was associated with a significantly larger extent of activation in the cerebellar hemispheres and the red nucleus (p < 0.003) compared with mimicked tremor in the control group. Our FMRI study indicates that ET is mainly associated with an additional. contralateral cerebellar pathway activation and overactivity in the cerebellum, red nucleus, and globus pallidus without significant intrinsic olivary activation.