Relationship between biologic behavior and phenotypic expression in intramucosal gastric carcinomas
Relationship between biologic behavior and phenotypic expression in intramucosal gastric carcinomas
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DOI：
10.1053/hupa.2002.30182
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发表时间：
2002-01-01
期刊：
影响因子：
3.3
通讯作者：
Tsuneyoshi, M
中科院分区：
文献类型：
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作者：
Kabashima, A;Yao, T;Tsuneyoshi, M
我们研究了胃癌表型的生物学行为，特别是与细胞外基质降解的关系。本文对114例分化型胃粘膜内癌进行了研究。结合CD 10、MUC 2、HGM和Con A的表达将IMGC分为4种表型：完全肠型（C型）、不完全肠型（I型）、胃型（G型）和未分类型。免疫组化法检测MMP-2、MMP-9、TIMP-2和IV型胶原的表达。C型IMGC、I型IMGC和G型IMGC的发生率分别为7.9%、55.3%和36.8%。MMP-9在G型IMGC中的阳性表达率（57%）明显高于C型IMGC（11%）和I型IMGC（35%）（P < 0.1）。表型与MMP-2、TIMP-2或IV型胶原的表达之间无显著相关性。IV型胶原的表达与IV型胶原酶的表达呈负相关（P <0.001）。总之，胃表型癌已被证明是高度侵袭性和转移性的，然而，尽管与肠表型癌相比，它们可以通过MMPs的过度表达而潜在地降解细胞外基质，但我们的数据显示，基于大体分类、组织学类型、淋巴或静脉浸润或淋巴结转移，粘膜内胃癌的亚型没有统计学显著的分离。Copyright（C）2002 by W.B.桑德斯公司
We investigated the biologic behavior of gastric phenotype carcinoma of the stomach, especially in association with degradation of the extracellular matrix. One hundred fourteen lesions of intramucosal gastric carcinoma (IMGC) of differentiated type were studied. IMGCs were classified into 4 phenotypic categories-complete intestinal type (C type), incomplete intestinal type (I type), gastric type (G type), and unclassified type-through a combination of the expression of CD10, MUC2, HGM, and Con A. The expression of MMP-2, MMP-9, TIMP-2, and type IV collagen was investigated by immunohistochemical staining. The incidence of C-type IMGC, I-type IMGC, and G-type IMGC was 7.9%, 55.3%, and 36.8%, respectively. The incidence of positive MMP-9 expression in G-type IMGCs (57%) was significantly higher than that in C-type IMGCs (11%) or I-type IMGCs (35%) (P < 0.1). There was no significant correlation between phenotypes and expression of MMP-2, TIMP-2, or type IV collagen. There was a reverse correlation between the expression of type IV collagen and the expression of type IV collagenase (P < .001). In conclusion, gastric phenotype carcinomas have been shown to be highly invasive and metastatic, However, although they can potentially degrade the extracellular matrix via overexpression of MMPs compared with intestinal phenotype carcinoma, our data show no statistically significant separation of subtypes of intramucosal gastric cancer based on gross classification, histologic type, lymphatic or venous invasion, or lymph node metastases. Copyright (C) 2002 by W.B. Saunders Company.