Predicting auditory feedback control of speech production from subregional shape of subcortical structures
Predicting auditory feedback control of speech production from subregional shape of subcortical structures
复制标题
从皮层下结构的次区域形状预测语音产生的听觉反馈控制
DOI：
10.1002/hbm.23855
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发表时间：
2018
影响因子：
4.8
通讯作者：
Liu Hanjun
中科院分区：
文献类型：
--
作者：
Tang Xiaoying;Chen Na;Zhang Siyun;Jones Jeffery A.;Zhang Baofeng;Li Jingyuan;Liu Peng;Liu Hanjun
尽管越来越多的研究集中在支持听觉反馈控制语言产生的皮层感觉运动机制上，但对皮层下对这一控制过程的贡献知之甚少。本研究考察了统计形状分析评估的皮层下结构的分区域解剖是否与音调反馈错误的声音补偿和皮层事件相关电位有关。结果表明，声音代偿的大小与右侧丘脑分区域形状、声音代偿的潜伏期与左侧尾状核和脑白质分区域形状、皮层N1反应的潜伏期与左侧壳核分区域形状呈显著负相关。这些关联表明，基底神经节和丘脑的局部体积较小，预示着对音高错误的更慢、更大的神经行为反应。此外，左侧海马体和右侧杏仁核局部体积的增加预示着更大的声音补偿，这表明与记忆相关的皮层下结构和听觉-声音整合之间存在相互作用。这些结果首次为基底神经节、丘脑、海马体和杏仁核的分区域形态与音高错误的神经行为处理之间的差异关联提供了证据，表明皮层下结构的分区域形状测量可以预测听-声整合的行为结果和相关的神经特征。脑电学报，2018,39(4):459 - 471。©2017 Wiley期刊公司
Although a growing body of research has focused on the cortical sensorimotor mechanisms that support auditory feedback control of speech production, much less is known about the subcortical contributions to this control process. This study examined whether subregional anatomy of subcortical structures assessed by statistical shape analysis is associated with vocal compensations and cortical event‐related potentials in response to pitch feedback errors. The results revealed significant negative correlations between the magnitudes of vocal compensations and subregional shape of the right thalamus, between the latencies of vocal compensations and subregional shape of the left caudate and pallidum, and between the latencies of cortical N1 responses and subregional shape of the left putamen. These associations indicate that smaller local volumes of the basal ganglia and thalamus are predictive of slower and larger neurobehavioral responses to vocal pitch errors. Furthermore, increased local volumes of the left hippocampus and right amygdala were predictive of larger vocal compensations, suggesting that there is an interplay between the memory‐related subcortical structures and auditory‐vocal integration. These results, for the first time, provide evidence for differential associations of subregional morphology of the basal ganglia, thalamus, hippocampus, and amygdala with neurobehavioral processing of vocal pitch errors, suggesting that subregional shape measures of subcortical structures can predict behavioral outcome of auditory‐vocal integration and associated neural features. Hum Brain Mapp 39:459–471, 2018. © 2017 Wiley Periodicals, Inc.