Treatment of AL amyloidosis with melphalan, prednisone, and colchicine.
Treatment of AL amyloidosis with melphalan, prednisone, and colchicine.
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用马法兰、泼尼松和秋水仙碱治疗 AL 淀粉样变性。
DOI：
10.1002/art.1780290515
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发表时间：
1986
影响因子：
--
通讯作者：
Benson,MD
中科院分区：
文献类型：
--
作者：
Benson,MD
7例免疫球蛋白型（AL）淀粉样变性患者接受联合化疗，包括美法仑、泼尼松和秋水仙碱。两名患者在治疗开始后5个月内死亡。两人都患有淀粉样心肌病。5名患者在治疗开始后存活了17-60个月，没有显示疾病进展。最显著的发现是2例患者的肾病综合征消退，2例患者的肝功能改善，如吲哚菁绿色排泄所示。这些结果是令人鼓舞的，并支持需要进一步研究这种联合化疗方案的患者与AL淀粉样变性。
Seven patients with immunoglobulin type (AL) amyloidosis were treated with combination chemotherapy, including melphalan, prednisone, and colchicine. Two patients died within 5 months of the beginning of therapy. Both had amyloid cardiomyopathy. Five patients were alive 17–60 months after the start of therapy, and none had shown progression of disease. The most significant findings were the resolution of the nephrotic syndrome in 2 patients, and improvement of liver function, as demonstrated by excretion of indocyanine green, in 2 patients. These results are encouraging and support the need for further studies of this regimen of combination chemotherapy for patients with AL amyloidosis.