Assessment of the role of inheritance in sleep apnea syndrome.
Assessment of the role of inheritance in sleep apnea syndrome.
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评估遗传在睡眠呼吸暂停综合征中的作用。
DOI：
10.1164/ajrccm/151.3_pt_1.688
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发表时间：
1995
影响因子：
24.7
通讯作者：
P. Lavie
中科院分区：
文献类型：
--
作者：
G. Pillar;P. Lavie
一些报告表明，遗传在睡眠呼吸暂停综合征（SAS）的发病机制中具有重要意义。在这项研究中，所有成年（> 16岁）的后代，45个随机选择的父母与先前诊断的SAS被要求进行一个通宵多导睡眠图研究。120名候选人中有105名参加了这项研究（66名男性：39名女性），依从率很高。47%的后代（36名男性和13名女性;平均年龄，32岁）被发现患有SAS。这些结果明显高于（p < 0.001）一般估计的人群中SAS患病率（4%）。另外21.9%的后代是“单纯打鼾者”（17名男性和6名女性;平均年龄= 26岁）。31%未受影响（13名男性，20名女性;平均年龄29岁）。只有16%的35岁以上的男性未受影响。在一个父母都受影响的家庭中，他们的三个孩子（儿子）都有SAS：两个16岁以上的孙子是单纯的打鼾者。考虑到SAS在一般人群中的普遍患病率（1 - 4%），这些结果可能表明SAS是一种遗传综合征。
Several reports have suggested a genetic importance in the pathogenesis of the sleep apnea syndrome (SAS). In this study, all adult (> 16 yr of age) offspring of 45 randomly selected parents with previously diagnosed SAS were asked to undergo a whole-night polysomnographic study. One hundred and five of 120 candidates participated in the study (66M:39F), with a high rate of compliance. Forty-seven percent of the offspring (36 males and 13 females; mean age, 32 yr) were found to have SAS. These results appear considerably higher (p < 0.001) than the common estimation of the prevalence of SAS in the population (4%). Another 21.9% of the offspring were "simple snorers" (17 males and 6 females; mean age, = 26 yr). Thirty-one percent were unaffected (13 males, 20 females; mean age, 29 yr). Only 16% of males over 35 yr of age were unaffected. In the single family studied in which both parents were affected, all three of their children (sons) had SAS: two grandsons older than 16 yr were simple snorers. Considering the well-established prevalence of SAS in the general population (1 to 4%), these results may suggest that SAS is an inherited syndrome.