Effect of antibacterial honey on the ocular flora in tear deficiency and meibomian gland disease
Effect of antibacterial honey on the ocular flora in tear deficiency and meibomian gland disease
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DOI：
10.1097/01.ico.0000225716.85382.7b
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发表时间：
2006-10-01
期刊：
影响因子：
2.8
通讯作者：
Lenton, Lee M.
中科院分区：
文献类型：
--
作者：
Albietz, Julie M.;Lenton, Lee M.
目的：评估泪液缺乏和/或睑板腺疾病引起的干眼症患者眼部植物群的差异，并评估抗菌蜂蜜对这些形式的干眼症患者眼部植物群的影响。方法：在这项前瞻性、开放标签的初步研究中，从眼睑边缘和结膜分离的细菌在开始用局部抗真菌药物治疗之前和之后1个月和3个月被鉴定和定量。抗菌蜂蜜每日3次。受试者患有非干燥性泪液缺乏症（n = 20）、干燥综合征泪液缺乏症（n = 11）、睑板腺疾病（n = 15）和非干燥性泪液缺乏症伴睑板腺疾病（n = 20），并且有18名非干眼症受试者。总集落形成单位（CFU）在使用抗菌蜂蜜之前，从每个干眼亚组中分离的总CFU显著大于从非干眼组中分离的总CFU。使用抗菌蜂蜜显著降低干眼受试者的眼睑和结膜的总CFU，从第1个月（眼睑：P = 0.0177，结膜：P = 0.0022）和第3个月（眼睑：P < 0.0001，结膜：P < 0.0001）的基线。在第3个月，所有干眼症亚组的总CFU均减少，使得CFU与非干眼症组的CFU没有显著差异。结论：从这些结果中，有足够的初步数据来保证进一步研究抗菌蜂蜜在慢性眼表疾病中的作用。
Purpose: To assess for differences in the ocular flora of patients with dry eye caused by tear deficiency and/or meibomian gland disease and to assess the effect of antibacterial honey on the ocular flora in these forms of dry eye.Methods: In this prospective, open-label pilot study, bacteria isolated from the eyelid margin and conjunctiva were identified and quantified before and at I and 3 months after initiation of treatment with topical application of antibacterial honey 3 times daily. Subjects had non-Sjogren tear deficiency (n = 20), Sjogren syndrome tear deficiency (n = 11), meibomian gland disease (n = 15), and non-Sjogren tear deficiency with meibomian gland disease (n = 20), and there were 18 non-dry eye subjects.Results: The total colony-forming units (CFUs) isolated from each of the dry eye subgroups before antibacterial honey use was significantly greater than the total CFU isolated from the non-dry eye group. Antibacterial honey use significantly reduced total CFUs for the eyelids and the conjunctiva of dry eye subjects from baseline at month I (eyelids: P = 0.0177, conjunctiva: P = 0.0022) and month 3 (eyelids: P < 0.0001, conjunctiva: P < 0.0001). At month 3, there were reductions in total CFUs for all dry eye subgroups such that the CFUs were not significantly different from those of the non-dry eye group,Conclusion: From these results there is sufficient preliminary data to warrant further study of the effects of antibacterial honey in chronic ocular surface diseases.