Effects of pre-germinated brown rice on β-amyloid protein-induced learning and memory deficits in mice
Effects of pre-germinated brown rice on β-amyloid protein-induced learning and memory deficits in mice
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DOI：
10.1248/bpb.27.1041
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发表时间：
2004-07-01
影响因子：
2
通讯作者：
Ukai, M
中科院分区：
文献类型：
--
作者：
Mamiya, T;Asanuma, T;Ukai, M
我们评估了发芽糙米（Hatsuga genmai，PGR）对学习和记忆的影响，并将其与精米或玉米淀粉进行了比较。在喂食精米或PGR颗粒两周的小鼠中，与喂食玉米淀粉颗粒的小鼠相比，Morris水迷宫测试中的学习能力显着增强。在Y-迷宫测试中，摄入食物颗粒两周未能影响自发交替行为。β-淀粉样蛋白（25-35）（Abeta（25-35）：3 nmol/小鼠，i. c. v.）蛋白质损害了喂食玉米淀粉或精米颗粒的小鼠的自发交替行为。相比之下，PGR颗粒防止了Abeta（25-35）诱导的自发交替行为的损害。这些结果表明，精米和PGR对空间学习有促进作用。特别地，推测PGR可以预防与Abeta相关的阿尔茨海默病。
We evaluated the effects of pre-germinated brown rice (hatsuga genmai, PGR) on learning and memory and compared them with those of polished rice or cornstarch. In mice that were fed pellets of polished rice or PGR for two weeks, the learning ability in the Morris water maze test was significantly enhanced compared with mice that were fed cornstarch pellets. In the Y-maze test, the intake of food pellets for two weeks failed to affect spontaneous alternation behavior. beta-Amyloid(25-35) (Abeta(25-35): 3 nmol/mouse, i.c.v.) protein impaired spontaneous alternation behavior in mice that were fed pellets of cornstarch or polished rice. In contrast, PGR pellets prevented the Abeta(25-35)-induced impairment of spontaneous alternation behavior. These results suggest that polished rice and PGR have facilitating effects on spatial learning. In particular, it is surmised that PGR may prevent Alzheimer's disease associated with Abeta.