On the Origin and Diagnostic Criteria of Olfactory Neuroblastoma
On the Origin and Diagnostic Criteria of Olfactory Neuroblastoma
复制标题
嗅神经母细胞瘤的起源及诊断标准
DOI：
10.1267/ahc.30.181
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发表时间：
1997
影响因子：
2.4
通讯作者：
Y. Ochi
中科院分区：
文献类型：
--
作者：
H. Okabe;T. Okubo;Y. Ochi
嗅觉神经母细胞瘤的起源和诊断标准仍有争议。为了解决这些问题，我们对7例符合Choi和Anderson诊断标准的嗅神经母细胞瘤进行了免疫组织化学分析，采用抗体检测发育和成熟的人嗅觉基板来源神经元中表达的标志物，如角蛋白、34 kDa上皮膜糖蛋白、黄体生成素-激素释放激素（LHRH）和其他神经组织标志物。并进行了超微结构分析。5例因显露神经突而被确定为神经母细胞瘤。这5例患者均对肿瘤细胞体和/或神经突中34 kDa上皮膜糖蛋白（Ber-EP4）的抗体具有广泛的免疫反应性。它们也含有角蛋白阳性细胞。其中2例Ber-EP4阳性神经母细胞瘤显示LHRH。这5例患者的免疫组化谱与正常嗅觉基因产生的神经母细胞相同。因此，我们得出结论，确实存在真正的嗅觉胎盘源性神经母细胞瘤。该肿瘤的诊断标准如下：表现出神经突和对Ber-EP4和/或LHRH的免疫反应。在这种肿瘤中，角蛋白不需要作为上皮分化的证据。
The origin and diagnostic criteria of olfactory neuroblastoma are still under dispute. Tosolve these problems, seven cases of olfactory neuroblastomas satisfying diagnostic criteria of Choi and Anderson were analyzed immunohistochemically by using antibodies to markers expressed in developing and mature human olfactory placode-derived neurons such as keratin, a 34 kDa epithelial membrane glycoprotein, luteinizing-hormone-releasing-hormone (LHRH) and to other neural tissue markers. Ultrastructural analysis was also carried out. Five cases were identified as neuroblastomas because neurites were disclosed in them. All of these five cases had widespread immunoreactivity to an antibody to a 34 kDa epithelial membrane glycoprotein (Ber-EP4) in the tumor cell bodies and/or neuritic processes. They also contained keratin positive cells. LHRH was demonstrated in two of these Ber-EP4 positive neuroblastomas. The spectrum of immunohistochemical findings of these five cases was identical to the normal neuroblasts arising from olfactory placode.Accordingly, it is concluded that neuroblastoma of true olfactory placodal origin does exist. The diagnostic criteria of this tumor is as follows: demonstration of neurites and immunoreactivity to Ber-EP4 and/or LHRH. Keratin is not necessary to regard as an evidence of epithelial differentiation in this tumor.
DOI：
10.1056/nejm198207153070305
发表时间：
1982-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
J. Trojanowski;V. Lee;N. Pillsbury;S. Lee
通讯作者：
J. Trojanowski;V. Lee;N. Pillsbury;S. Lee