The serrated neoplasia pathway
The serrated neoplasia pathway
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DOI：
10.1080/0031302021000035965
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发表时间：
2002-12-01
期刊：
影响因子：
4.5
通讯作者：
Ward, RL
中科院分区：
文献类型：
--
作者：
Hawkins, NJ;Bariol, C;Ward, RL
“锯齿状瘤形成途径”的概念是指结肠和直肠肿瘤的进展模式，涉及增生性息肉和锯齿状腺瘤，并导致癌的发展。这一途径的存在最初是基于形态学的基础上提出的。在过去的几年里，越来越多的认识到生物学和遗传相似性的病变，这一途径有助于加强这一概念。可能存在这样一个独特的途径，结直肠癌的外科病理学的做法有影响。最值得注意的是，它需要病理学家识别锯齿状腺瘤的实体，并识别可能与肿瘤进展相关的增生性息肉的特征。
The concept of a 'serrated neoplasia pathway' refers to a pattern of progression of neoplasms of the colon and rectum that involves hyperplastic polyps and serrated adenomas and which results in the development of carcinoma. The existence of this pathway was initially suggested on morphological grounds. Over the past few years, the increasing recognition of biological and genetic similarities in lesions of this pathway has served to reinforce this concept. The likely existence of such a distinct pathway of colorectal carcinogenesis has implications for the practice of surgical pathology. Most notably, it requires pathologists to recognise the entity of the serrated adenoma, and also to recognise those features of hyperplastic polyps that may be associated with a potential for neoplastic progression.