Synthesis and characterization of mesoporous and hollow-mesoporous MxFe3-xO4 (M=Mg, Mn, Fe, Co, Ni, Cu, Zn) microspheres for microwave-triggered controllable drug delivery
Synthesis and characterization of mesoporous and hollow-mesoporous MxFe3-xO4 (M=Mg, Mn, Fe, Co, Ni, Cu, Zn) microspheres for microwave-triggered controllable drug delivery
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DOI：
10.1007/s11051-017-4096-z
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发表时间：
2017-12-09
影响因子：
2.5
通讯作者：
Wang, Yaoyu
中科院分区：
文献类型：
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作者：
Chen, Ping;Cui, Bin;Wang, Yaoyu
尖晶石铁氧体可用于磁靶向和微波加热，因此可用于靶向和可控药物输送。我们采用十六烷基三甲基溴化铵辅助溶剂热法合成了一系列适合直接载药的介孔或中空介孔结构的尖晶石铁氧体（MxFe3-xO4，M= Mg、Mn、Fe、Co、Ni、Cu、Zn），粒径范围为200至350 nm。我们通过分析透射电子显微镜图像、介孔性能、磁性和微波响应，研究了 M2+ 阳离子对这些产品的形态和性能的影响。我们选择了具有更好综合性能的中空介孔MxFe3-xO4（M= Fe、Co、Zn）纳米颗粒用于药物VP16（依托泊苷）的负载和微波控释。 CoxFe3-xO4 和 Fe3O4 颗粒对 VP16 的捕获率分别为 61.5% 和 64.8%，高于 ZnxFe3-xO4 的捕获率（60.4%）。这些简单的磁性纳米载体可以通过微波辐射实现可控药物释放，并且负载VP16的CoxFe3-xO4在微波辐射下释放最多的VP16分子（1小时后超过50%，6小时后超过69.1%）。我们的研究结果证实了这些铁氧体具有良好的载药性和微波控制递送性能，为推广靶向可控药物递送系统的临床应用奠定了理论基础。本研究采用CTAB辅助溶剂热法制备了介孔或空心介孔尖晶石铁氧体（MxFe3-xO4，M= Mg，Mn，Fe，Co，Ni，Cu，Zn），解决了靶向可控药物递送系统中Cu和Ni杂质的问题。 CuxFe3-xO4 和 NixFe3-xO4 分别通过磁分离和附加氧化还原反应生成。我们研究了 M2+ 阳离子对这些铁氧体的形态、介孔性能、磁性和微波响应的影响。然后，还研究了综合性能更好的中空介孔MxFe3-xO4（M=Fe、Co、Zn）纳米粒子的载药和微波控制药物释放。 CoxFe3-xO4 具有最佳的微波控制药物释放综合性能。
Spinel ferrites can be used in magnetic targeting and microwave heating and can therefore be used for targeted and controllable drug delivery. We used the cetyltrimethylammonium bromide-assisted solvothermal method to synthesize a series of spinel ferrites (MxFe3-xO4, M= Mg, Mn, Fe, Co, Ni, Cu, Zn) with a mesoporous or hollow-mesoporous structure suitable for direct drug loading and the particle diameters ranging from 200 to 350 nm. We investigated the effects of M2+ cation on the morphology and properties of these products by analyzing their transmission electron microscopy images, mesoporous properties, magnetic properties, and microwave responses. We chose hollow-mesoporous MxFe3-xO4 (M= Fe, Co, Zn) nanoparticles, which had better overall properties, for the drug VP16 (etoposide) loading and microwavecontrolled release. The CoxFe3-xO4 and Fe3O4 particles trapped 61.5 and 64.8%, respectively, of the VP16, which were higher than that (60.4%) of ZnxFe3-xO4. Controllable drug release by these simple magnetic nanocarriers can be achieved by microwave irradiation, and VP16-loaded CoxFe3-xO4 released the most VP16 molecules (more than 50% after 1 h and 69.1% after 6 h) under microwave irradiation. Our results confirm the favorable drug loading and microwave-controlled delivery by these ferrites, and lay a theoretical foundation to promote clinical application of the targeted controllable drug delivery system.In the present study, we prepared mesoporous or hollow-mesoporous spinel ferrites (MxFe3-xO4, M= Mg, Mn, Fe, Co, Ni, Cu, Zn) by CTAB-assisted solvothermal method and solved the problem of Cu and Ni impurities in CuxFe3-xO4 and NixFe3-xO4 products by means of magnetic separation and additional redox reactions, respectively. We investigated the effects of the M2+ cation on the morphology, mesoporous properties, magnetic properties, and microwave responses of these ferrites. Then, the drug loading and microwave-controlled drug release of hollow-mesoporous MxFe3-xO4 (M = Fe, Co, Zn) nanoparticles with better overall properties were also studied. CoxFe3-xO4 has the best overall performances for microwave-controlled drug release.