Risk and Protective Factors Related to Early Adverse Life Events in Irritable Bowel Syndrome
Risk and Protective Factors Related to Early Adverse Life Events in Irritable Bowel Syndrome
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DOI：
10.1097/mcg.0000000000001153
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发表时间：
2020-01-01
影响因子：
2.9
通讯作者：
Chang, Lin
中科院分区：
文献类型：
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作者：
Ju, Tiffany;Naliboff, Bruce D.;Chang, Lin
背景：肠易激综合征(IBS)是一种脑-肠道相互作用的应激敏感障碍，与早期不良生活事件(EALS)的发生率较高相关。目的：确定(1)IBS患者报告的EAL数量是否高于健康对照组；(2)创伤严重程度和EAL的年龄是否增加了IBS的发病几率；(3)向他人吐露信息降低了IBS的发病几率；(4)EAL的个数、创伤严重程度和EAL的年龄与症状严重程度相关；(5)性别差异。方法：总共有197例IBS患者(72%女性，平均年龄30.28岁)和165例健康对照(59%女性，平均年龄30.77岁)完成了儿童创伤事件量表，测量EALS的严重程度和对他人的信任程度。结果：EALS患者的优势比(OR)=1.36，95%可信区间(CI)为1.14~1.62；
Background:Irritable bowel syndrome (IBS) is a stress-sensitive disorder of brain-gut interactions associated with a higher prevalence of early adverse life events (EALs). However, it is incompletely understood how trauma severity or disclosure influence the risk of developing IBS or symptom severity.Aims:To determine whether (1) IBS patients report a greater number of EALs compared with healthy controls; (2) trauma severity and first age of EAL increase the odds of IBS; (3) confiding in others reduces the odds of IBS; (4) the number, trauma severity, and first age of EAL are associated with symptom severity; (5) sex differences exist.Methods:In total, 197 IBS patients (72% women, mean age=30.28y) and 165 healthy controls (59% women, mean age=30.77y) completed the Childhood Traumatic Events Scale, measuring severity of EALs and degree of confiding in others. Regression analyses were used to predict IBS status from EALs and association between gastrointestinal symptoms and EALs.Results:A greater number of EALs [odds ratio (OR)=1.36, 95% confidence interval (CI), 1.14-1.62; P