Shape differences of the brain ventricles in Alzheimer's disease
Shape differences of the brain ventricles in Alzheimer's disease
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DOI：
10.1016/j.neuroimage.2006.05.048
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发表时间：
2006-09-01
期刊：
影响因子：
5.7
通讯作者：
Admiraal-Behloul, Faiza
中科院分区：
文献类型：
--
作者：
Ferrarini, Luca;Palm, Walter M.;Admiraal-Behloul, Faiza
脑室周围是灰质和白质结构，通常在痴呆症中受到影响，特别是阿尔茨海默病（AD）。在这些结构中发生的体积或形状的任何变化都必须影响心室的体积和形状。众所周知，与年龄匹配的健康受试者相比，AD患者的心室容积明显更高。然而，两种体积分布之间的大重叠使得测量不适合作为疾病的生物标志物。这项工作的目的是评估在比较AD患者和对照组时是否可以检测到心室的局部形状差异。在这项工作中，我们使用全自动形状建模技术捕获了29名AD受试者和25名年龄匹配的对照组的心室形状和形状变化。通过对形状的网格表示的每个节点应用排列测试，我们识别出具有显著差异的局部区域。约22%的心室平均表面有显著性差异（P < 0.05）（左侧相似14%，右侧相似7%）。我们发现，在阿尔茨海默病患者中，不仅侧角受到明显影响，胼胝体前部、胼胝体的脾脏、杏仁核、丘脑、尾状核前部（尤其是左侧）和左侧尾状核头部附近的区域也受到明显影响。(c) 2006爱思唯尔公司版权所有。
The brain ventricles are surrounded by gray and white matter structures that are often affected in dementia in general and Alzheimer's disease (AD) in particular. Any change of volume or shape occurring in these structures must affect the volume and shape of the ventricles. It is well known that ventricular volume is significantly higher in AD patients compared to age-matched healthy subjects. However, the large overlap between the two volume distributions makes the measurement unsuitable as a biomarker of the disease. The purpose of this work was to assess whether local shape differences of the ventricles can be detected when comparing AD patients and controls. In this work, we captured the ventricle's shape and shape variations of 29 AD subjects and 25 age-matched controls, using a fully automatic shape modeling technique. By applying permutation tests on every single node of a mesh representation of the shapes, we identified local areas with significant differences. About 22% of an average surface of the ventricles presented significant difference (P < 0.05) (similar to 14% of the left against similar to 7% of the right side). We found out that in patients with Alzheimer disease, not only the lateral horns were significantly affected, but also the areas adjacent to the anterior corpus callosum, the splenium of the corpus callosum, the amygdala, the thalamus, the tale of the caudate nuclei (especially the left one), and the head of the left caudate nucleus. (c) 2006 Elsevier Inc. All rights reserved.