Developmental origins of noncommunicable disease: population and public health implications
Developmental origins of noncommunicable disease: population and public health implications
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DOI：
10.3945/ajcn.110.001206
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发表时间：
2011-12-01
影响因子：
7.1
通讯作者：
Gluckman, Peter
中科院分区：
文献类型：
--
作者：
Hanson, Mark;Gluckman, Peter
非传染性疾病，包括心血管疾病、糖尿病、慢性肺病、过敏、某些形式的癌症、认知能力下降、骨质疏松症、肌肉减少症和情感性疾病，是世界上最大的杀手。这些死亡中有80%发生在低收入和中等收入国家，特别是这些国家在传染病减少后社会经济得到改善。世界卫生组织预测，未来十年全球非传染性疾病将增加17%。非传染性疾病是可以预防的，但需要采取新的行动来开展这种预防，特别是在生命早期。在这篇文章中，我们强调所有儿童都受到他们早期发育条件的影响，而不仅仅是暴露在非常缺乏的环境中的儿童，这对他们患非传染性疾病的易感性有长期影响。我们强调这种健康和疾病的发展起源（DOHaD）概念的非传染性疾病的生物医学意义，并讨论对卫生政策的影响。中华临床医学杂志，2011;14（增刊）：175s - 8s。
Noncommunicable diseases (NCDs), including cardiovascular disease, diabetes, chronic lung disease, allergy, some forms of cancer, cognitive decline, osteoporosis, sarcopenia, and affective disorders, are the world's biggest killers. Eighty percent of these deaths occur in low-and middle-income countries, especially as these countries undergo socioeconomic improvement after reductions in infectious disease. The World Health Organization predicts a global increase of 17% in NCDs over the next decade. NCDs are preventable, but new initiatives are needed to institute such prevention, especially in early life. In this article, we emphasize that all children are affected by their early developmental conditions, not just children exposed to a very deficient environment, and that this has long-term consequences for their predisposition to NCDs. We highlight the biomedical implications of this developmental origins of health and disease (DOHaD) concept of NCDs and discuss the implications for health policy. Am J Clin Nutr 2011;94(suppl):1754S-8S.