Extrachromosomal control of mutability in Drosophila melanogaster.
Extrachromosomal control of mutability in Drosophila melanogaster.
复制标题
果蝇突变性的染色体外控制。
DOI：
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发表时间：
1979
影响因子：
11.1
通讯作者：
W. Engels
中科院分区：
文献类型：
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作者：
W. Engels
杂种发育不全是生殖系畸变的综合征，包括，例如，不育和突变，发现于某些品系间杂交的果蝇。先前的不育研究表明，导致发育不全的因素可能存在于所有主要染色体上，但它们导致发育不全的能力是由未知的染色体外因素控制的。异基因杂种也会产生不稳定的可见突变，这些突变被认为是某些敏感基因座的DNA插入。在烧焦的猪鬃位点上有一个这样的不稳定等位基因，命名为snw，被发现以超过50%的惊人速度突变。这种不稳定性被证明是在相同的染色体外控制的杂种不育本身。也就是说，当置于背景细胞型中时，snw的突变性被可逆地抑制，已知这种背景细胞型可以防止不育和杂交后代发育不全的其他特征。这些结果表明，snw可能代表一个假设的基因负责杂种发育不全的烧焦位点的插入。
Hybrid dysgenesis is a syndrome of germ-line aberrations including, e.g., sterility and mutation, found in certain interstrain hybrids of Drosophila melanogaster. Previous studies of sterility have shown that elements responsible for dysgenesis may reside on all major chromosomes, but that their dysgenesis-causing ability is controlled by an unknown extrachromosomal factor. Dysgenic hybrids also give rise to unstable visible mutations thought to be DNA insertions at certain sensitive loci. One such unstable allele at the singed bristle locus, designated snw, was found to mutate at extraordinary rates exceeding 50%. This instability was shown to be under the same extrachromosomal control as hybrid dysgenesis itself. That is, the mutability of snw was reversibly suppressed when placed in the background cytotype known to prevent sterility and other characteristics of hybrid dysgenesis. These results suggest that snw may represent an insertion at the singed locus of a hypothetical gene responsible for hybrid dysgenesis.