CSF and ECF glutamate concentrations in head injured patients.
CSF and ECF glutamate concentrations in head injured patients.
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头部受伤患者的 CSF 和 ECF 谷氨酸浓度。
DOI：
10.1007/978-3-7091-6415-0_4
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Anthony Marmarou
中科院分区：
文献类型：
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作者：
T. Yamamoto;S. Rossi;Michael F. Stiefel;E. Doppenberg;A. Zauner;Ross Bullock;Anthony Marmarou
兴奋性氨基酸（EAAs）释放被认为是外伤性脑损伤患者的神经毒性。外伤性脑损伤（TBI）后的细胞外间隙（ECS）和脑脊液（CSF）中高谷氨酸浓度的微透析样本已被记录。本研究的目的是确定局灶性和弥漫性损伤时ECS和CSF中EAA释放的相关性。对弗吉尼亚医学院医院收治的颅脑损伤患者（GCS < or = 8, n = 16）进行ECS微透析采集。在损伤后的头4天，每隔4小时通过脑室外引流管收集脑脊液样本。取正常压力性脑积水患者脑脊液作为对照组（n = 6）。脑损伤后脑脊液和ECS中谷氨酸水平均升高。脑脊液谷氨酸平均浓度（3.20 +/- 3.62 mumol/l）较对照组（1.13 +/- 0.49 mumol/l）显著升高（p < 0.05）。脑脊液和细胞外液（ECF）样品的比较表明，谷氨酸浓度在第1天和第2天最高，在第3天和第4天逐渐下降。在第4天，谷氨酸水平仍然高于正常水平。
Excitatory Amino Acids (EAAs) release has been considered to be neurotoxic in traumatic brain injury patients. Microdialysis samples of extracellular space (ECS) and high glutamate concentrations in cerebrospinal fluid (CSF) following Traumatic Brain Injury (TBI) have been documented. The objective of this study was to determine the correlation between EAA release in ECS and CSF in focal and diffuse injury. Head injury patients (GCS < or = 8, n = 16) admitted to Medical College of Virginia Hospital were instrumented for microdialysis collection of ECS samples. CSF samples were collected through the external ventricular drainage catheter at four hour intervals for the first four days following injury. As a control group, CSF was collected from normal pressure hydrocephalus patients (n = 6). Elevated glutamate levels were observed in both CSF and ECS following head injury. The average glutamate concentration in CSF (3.20 +/- 3.62 mumol/l) was significantly increased from control levels (1.13 +/- 0.49 mumol/l, p < 0.05). Comparison of CSF and extracellular fluid (ECF) samples showed that the glutamate concentrations were maximal on the first and second days and gradually decreased on days 3 and 4. On days 4, the level of the glutamate had remained elevated above the normal level.