What do female rats like about sex? Paced mating
What do female rats like about sex? Paced mating
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DOI：
10.1016/s0166-4328(99)00087-x
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发表时间：
1999-11-01
影响因子：
2.7
通讯作者：
Vazquez, B
中科院分区：
文献类型：
--
作者：
Paredes, RG;Vazquez, B
女性性行为的动机方面已被评估的各种方法，包括：增加障碍的方法，跑道程序，合作伙伴偏好测试，操作性行为和条件位置偏好。当雌性大鼠在传统的实验室条件下进行性感受性测试时，通常是一个小的开放区域？性互动的欲望和厌恶成分都很容易观察到。例如，在长时间的测试之后，随后的脊柱前凸和这种反应的强度降低，增加了女性的排斥行为。然而，当雌性大鼠被允许调整（控制）它们所接受的性刺激的速率时，就像通常在自然和非自然条件下发生的那样，交配的厌恶性就会降低。条件性位置偏好可以用来衡量交配引起的积极影响。我们结合了起搏和条件性位置偏好，试图减少与交配相关的可能的令人厌恶的后果，并增加检测雌性大鼠性交相互作用的食欲影响的可能性。只有雌性大鼠，调节（节奏）他们的性交相互作用与螺柱男性通过一个双室室，其中只有女性可以自由地从一个隔间移动到其他开发了一个明确的位置偏好。同样，接受了10或15次节奏介绍（没有射精）的女性也会发展出位置偏好。纳洛酮的全身给药阻断了由节奏交配诱导的位置偏好，表明阿片类药物参与了与节奏交配相关的奖励过程。有节奏的性互动可以诱导足够强度和持续时间的积极影响，以诱导条件反射。(C)1999 Elsevier Science B.V.保留所有权利。
The motivational aspects of female sexual behavior have been evaluated by a variety of methodologies including: the increasing barrier method, the runway procedure, partner preference test, operant behavior and conditioned place preference. When female rats an tested for sexual receptivity under traditional laboratory conditions, usually a small open area? both appetitive and aversive components of the sexual interaction are easily observed. For example, after prolonged testing, subsequent lordosis and the intensity of this response are reduced increasing the rejection behavior by the female. However, when female rats are allowed to pace (control) the rate of sexual stimulation they received, as usually occurs under seminatural and natural conditions, the aversive properties of mating are reduced. The conditioned place preference can be use to measure the positive affect elicited by mating. We have combined pacing and conditioned place preference in an attempt to reduced the possible aversive consequences associated with mating and increase the likelihood of detecting the appetitive effects of coital interaction in female rats. Only female rats that regulated (paced) their coital interactions with a stud male through a two-compartment chamber in which only the female could freely move from one compartment to the other developed a clear place preference. As well, females that received ten or 15 paced intromissions (without ejaculation) also developed place preference. The place preference induce by paced mating is blocked by the systemic administration of naloxone suggesting that opioids are involved in the reward processes associated with paced mating. Paced sexual interactions can induce a positive affect of sufficient intensity and duration to induce conditioning. (C) 1999 Elsevier Science B.V. All rights reserved.