Variable frequencies of peripheral T-lymphocyte subsets in the diabetes spectrum from type 1 diabetes through latent autoimmune diabetes in adults (LADA) to type 2 diabetes.
Variable frequencies of peripheral T-lymphocyte subsets in the diabetes spectrum from type 1 diabetes through latent autoimmune diabetes in adults (LADA) to type 2 diabetes.
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DOI：
10.3389/fimmu.2022.974864
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发表时间：
2022
影响因子：
7.3
通讯作者：
Zhou, Zhiguang
中科院分区：
文献类型：
--
作者：
Tan, Tingting;Xiang, Yufei;Deng, Chao;Cao, Chuqing;Ren, Zhihui;Huang, Gan;Zhou, Zhiguang
T淋巴细胞是自身免疫性糖尿病发病机制中的关键参与者。我们招募了T1 D（n=81）、LADA（n=82）、T2 D（n=95）和NGT（n=218）受试者，并分析了T淋巴细胞亚群的百分比，包括T辅助细胞1（Th 1）、T辅助细胞2（Th 2）、T辅助细胞17（Th 17）、T细胞毒性1（Tc 1）、调节性T细胞（Tc 1）、效应T细胞（Teff）、幼稚T细胞、中枢记忆T细胞（Tcm）、和效应记忆T（Tem）细胞。LADA患者的IFN-γ+ CD 4 + T（Th 1）、IFN-γ+ CD 8 + T和CD 4 + Teff细胞与T1 D患者相似，但明显低于NGT患者。与T2 D患者一样，LADA患者的CD 4 + Tem和CD 8 + Tem细胞频率高于T1 D和NGT受试者。LADA患者Th 2细胞减少，CD 4 + Tcm细胞增加。值得注意的是，我们观察到LADA受试者的CD 4 + Tcm细胞频率和C肽之间存在显着的负相关性。这些数据表明，LADA患者具有类似T1 D和T2 D的T细胞亚群变化，代表T1 D和T2 D之间的糖尿病谱的中间。基于这些T细胞亚群的改变，我们推测自身免疫诱导的β细胞破坏和炎症诱导的胰岛素抵抗可能都参与了LADA的发病机制。
T lymphocytes are key players in the pathogenesis of autoimmune diabetes. We recruited subjects with T1D (n=81), LADA (n=82), T2D (n=95) and NGT (n=218) and analyzed the percentages of T-lymphocyte subsets, including T helper 1 (Th1), T helper 2 (Th2), T helper 17 (Th17), T cytotoxic 1 (Tc1), regulatory T cells (Tregs), effector T (Teff), naïve T, central memory T (Tcm), and effector memory T (Tem) cells by flow cytometry. LADA patients possessed similar frequencies of IFN-γ+CD4+ T (Th1), IFN-γ+CD8+ T and CD4+ Teff cells compared with T1D patients, but much lower than those of NGT subjects. Like T2D patients, LADA patients had increased frequencies of CD4+ Tem and CD8+ Tem cells with respect to T1D and NGT subjects. In LADA patients, Th2 cells were decreased while CD4+ Tcm cells were increased compared with NGT subjects. Notably, we observed significant negative correlations between the CD4+ Tcm cell frequency and C-peptide in LADA subjects. These data demonstrates that LADA patients possess T-cell subset changes resembling both T1D and T2D and represent the middle of the diabetes spectrum between T1D and T2D. Based on these T-cell subset alterations, we speculate that autoimmunity-induced β-cell destruction and inflammation-induced insulin resistance might both be involved in the pathogenesis of LADA.
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DOI：
10.4049/jimmunol.1002615
发表时间：
2011-01-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Jagannathan-Bogdan M;McDonnell ME;Shin H;Rehman Q;Hasturk H;Apovian CM;Nikolajczyk BS
通讯作者：
Nikolajczyk BS
影响因子：
16.2
作者：
Brooks-Worrell BM;Reichow JL;Goel A;Ismail H;Palmer JP
通讯作者：
Palmer JP
影响因子：
3.8
作者：
Liang, Huiying;Cheng, Ying;Zhou, Zhiguang
通讯作者：
Zhou, Zhiguang
DOI：
10.1002/oby.21243
发表时间：
2016-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Ip B;Cilfone NA;Belkina AC;DeFuria J;Jagannathan-Bogdan M;Zhu M;Kuchibhatla R;McDonnell ME;Xiao Q;Kepler TB;Apovian CM;Lauffenburger DA;Nikolajczyk BS
通讯作者：
Nikolajczyk BS
影响因子：
7.7
作者：
Orban T;Beam CA;Xu P;Moore K;Jiang Q;Deng J;Muller S;Gottlieb P;Spain L;Peakman M;Type 1 Diabetes TrialNet Abatacept Study Group
通讯作者：
Type 1 Diabetes TrialNet Abatacept Study Group