Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes
Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes
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DOI：
10.4161/cc.4.3.1551
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发表时间：
2005-03-01
期刊：
影响因子：
4.3
通讯作者：
Sicinski, P
中科院分区：
文献类型：
--
作者：
Kozar, K;Sicinski, P
D-type cyclins ( cyclin D1, D2 and D3) and their associated cyclin-dependent kinases CDK4 and CDK6 were thought to represent important, perhaps essential components of the core cell cycle apparatus. However, recent analyses of mice lacking D-cyclins, or CDK4 and CDK6 reveal that these proteins are critically required for proliferation only in the selected cell types. Intriguingly, several compartments can develop in the absence of cyclin D-CDK4/6 activity, revealing that these cells can proliferate in a cyclin D-independent fashion.
