THE TOXICITY AND METABOLISM OF DIHYDROQUERCETIN
THE TOXICITY AND METABOLISM OF DIHYDROQUERCETIN
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DOI：
10.1002/jps.3030470310
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发表时间：
1958-01-01
期刊：
影响因子：
--
通讯作者：
DEEDS, F
中科院分区：
文献类型：
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作者：
BOOTH, AN;DEEDS, F
当长期以 1% 的膳食水平喂食白化大鼠时，二氢槲皮素是无毒的。对 2 名志愿者摄入 2 克二氢槲皮素前后的尿液进行色谱检查，结果表明该化合物转化为 3,4-二羟基苯乙酸、间羟基苯乙酸和 3-甲氧基-4-羟基苯乙酸。大鼠、兔子或人类口服槲皮素或多巴[3-(3, 4-二羟基苯基)丙氨酸]后，这些相同的代谢物会被排出。
Dihydroquercetin is nontoxic when fed to albino rats at a dietary level of 1% for long periods of time. Chromatographic examination of the urine of 2 human volunteers before and after the ingestion of 2 g of dihydroquercetin demonstrated the conversion of the compound to 3,4-dihydroxyphenylacetic, m-hydroxyphenylacetic, and 3-methoxy-4-hydro-xyphenylacetic acids. These same metabolites are excreted following oral administration of quercetin, or DOPA [3-(3, 4-dihydroxyphenyl) alanine] to rats, rabbits, or humans.