Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli
Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli
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DOI：
10.1126/science.1093360
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发表时间：
2004-03-26
期刊：
影响因子：
56.9
通讯作者：
Bolam, JP
中科院分区：
文献类型：
--
作者：
Ungless, MA;Magill, PJ;Bolam, JP
多巴胺神经元在奖赏相关行为中起着关键作用。奖赏编码理论预测，多巴胺神经元会受到厌恶性刺激的抑制，或者不会对厌恶性刺激做出反应。奇怪的是，3%到49%的多巴胺神经元被厌恶刺激所兴奋。我们发现，在麻醉大鼠的腹侧被盖区，被厌恶刺激兴奋的假定多巴胺神经元群实际上不是多巴胺能的。识别出的多巴胺神经元被厌恶性刺激抑制。这些发现表明，多巴胺神经元特别兴奋的奖励和人口的非多巴胺神经元兴奋的厌恶刺激。
Dopamine neurons play a key role in reward-related behaviors. Reward coding theories predict that dopamine neurons will be inhibited by or will not respond to aversive stimuli. Paradoxically, between 3 and 49% of presumed dopamine neurons are excited by aversive stimuli. We found that, in the ventral tegmental area of anesthetized rats, the population of presumed dopamine neurons that are excited by aversive stimuli is actually not dopaminergic. The identified dopamine neurons were inhibited by the aversive stimulus. These findings suggest that dopamine neurons are specifically excited by reward and that a population of nondopamine neurons is excited by aversive stimuli.