The Effect of Abnormal Regional Homogeneity and Spontaneous Low-Frequency Brain Activity on Lower Cognitive Ability: A Cross-Sectional Study on Postoperative Children With Tetralogy of Fallot.
The Effect of Abnormal Regional Homogeneity and Spontaneous Low-Frequency Brain Activity on Lower Cognitive Ability: A Cross-Sectional Study on Postoperative Children With Tetralogy of Fallot.
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DOI：
10.3389/fnins.2021.685372
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发表时间：
2021
影响因子：
4.3
通讯作者：
Mo X
中科院分区：
文献类型：
--
作者：
Ma S;Hu Y;Liu Y;Pu Y;Zuo P;Hu Q;Yang Z;Chen F;Xie Z;Cun Y;Liu X;Yang M;Mo X
尽管心内畸形矫正，法洛四联症（TOF）儿童仍可能遭受脑损伤。这项横断面研究主要旨在确定学龄期TOF儿童手术后血氧水平依赖性（BOLD）信号变化与认知之间的关系。采用静息态功能磁共振成像（rs-fMRI）和韦氏儿童智力量表中文修订版（WISC-CR）对9例TOF儿童和9例健康儿童进行对比研究。结果表明，TOF儿童的全量表智商较低（FSIQ，95.444 ± 5.354，p = 0.022）和言语智商（VIQ，92.444 ± 4.708，p = 0.003）（FSIQ = 118.500 ± 4.330; VIQ = 124.250 ± 4.404），两组患者的局部均匀性（ReHo）和低频波动幅度（ALFF）差异有统计学意义。此外，在完全调整所有协变量后，VIQ与枕中下回的ALFF值下降（MIOG，β = 0.908，p = 0.012）呈显著正相关。此外，在MIOG中，左右楔前叶的ReHo值升高与ALFF呈正相关。这项研究表明，脑损伤在很大程度上影响了TOF儿童术后的神经活动和认知，提供了BOLD信号变化和VIQ之间相关性的直接证据，并促使人们进一步关注TOF儿童的语言发育。
Despite intracardiac malformation correction, children with Tetralogy of Fallot (TOF) may still suffer from brain injury. This cross-sectional study was primarily designed to determine the relationship between blood oxygenation level-dependent (BOLD) signal changes after surgery and cognition in school-aged children with TOF. To evaluate the differences between TOF children (n = 9) and healthy children (n = 9), resting-state functional magnetic resonance imaging (rs-fMRI) and the Wechsler Intelligence Scale for Children–Chinese revised edition (WISC-CR) were conducted in this study. The results showed that TOF children had a lower full-scale intelligence quotient (FSIQ, 95.444 ± 5.354, p = 0.022) and verbal intelligence quotient (VIQ, 92.444 ± 4.708, p = 0.003) than healthy children (FSIQ = 118.500 ± 4.330;VIQ = 124.250 ± 4.404), and that significant differences in regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) existed between the two groups. Besides, VIQ had significantly positive correlations with the decreased ALFF value of the middle inferior occipital gyrus (MIOG, beta = 0.908, p = 0.012) after fully adjusting for all covariates. In addition, elevated ReHo values of the left and right precuneus were positively related to ALFF in the MIOG. This study revealed that brain injury substantially influences neural activity and cognition in postoperative TOF children, providing direct evidence of an association between BOLD signal changes and the VIQ and prompting further attention to language development in TOF children.
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