Chondrocyte-specific knockout of the G protein Gsα leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation and growth plate abnormalities and ectopic chondrocyte formation
Chondrocyte-specific knockout of the G protein Gsα leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation and growth plate abnormalities and ectopic chondrocyte formation
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DOI：
10.1359/jbmr.041210
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发表时间：
2005-04-01
影响因子：
6.2
通讯作者：
Weinstein, LS
中科院分区：
文献类型：
--
作者：
Sakamoto, A;Chen, M;Weinstein, LS
G（s）α是一种广泛表达的G蛋白α亚基，其将受体与腺苷酸环化酶偶联。软骨细胞特异性去除G1 a基因的小鼠具有严重的骨骺和生长板异常，胫骨干骺端区域内异位软骨形成。这些结果表明，G（s）α负调节软骨细胞分化，是生长板软骨细胞中PTH/PTH-rP受体的关键信号介质。
G(s)alpha is a ubiquitously expressed G protein alpha-subunit that couples receptors to adenylyl cyclase. Mice with chondrocyte-specific ablation of the G,,a gene had severe epiphyseal and growth plate abnormalities and ectopic cartilage formation within the metaphyseal region of the tibia. These results show that G(s)alpha negatively regulates chondrocyte differentiation and is the critical signaling mediator of the PTH/PTH-rP receptor in growth plate chondrocytes.