Transposable Elements in Pluripotent Stem Cells and Human Disease.
Transposable Elements in Pluripotent Stem Cells and Human Disease.
复制标题
DOI：
10.3389/fgene.2022.902541
复制
发表时间：
2022
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
Transposable elements (TEs) are mobile genetic elements that can randomly integrate into other genomic sites. They have successfully replicated and now occupy around 40% of the total DNA sequence in humans. TEs in the genome have a complex relationship with the host cell, being both potentially deleterious and advantageous at the same time. Only a tiny minority of TEs are still capable of transposition, yet their fossilized sequence fragments are thought to be involved in various molecular processes, such as gene transcriptional activity, RNA stability and subcellular localization, and chromosomal architecture. TEs have also been implicated in biological processes, although it is often hard to reveal cause from correlation due to formidable technical issues in analyzing TEs. In this review, we compare and contrast two views of TE activity: one in the pluripotent state, where TEs are broadly beneficial, or at least mechanistically useful, and a second state in human disease, where TEs are uniformly considered harmful.
登录
查看更多内容
影响因子：
64.5
作者：
Attig J;Agostini F;Gooding C;Chakrabarti AM;Singh A;Haberman N;Zagalak JA;Emmett W;Smith CWJ;Luscombe NM;Ule J
通讯作者：
Ule J
影响因子：
14.9
作者：
Cruickshanks HA;Vafadar-Isfahani N;Dunican DS;Lee A;Sproul D;Lund JN;Meehan RR;Tufarelli C
通讯作者：
Tufarelli C
影响因子：
64.8
作者：
Agrawal, A;Eastman, QM;Schatz, DG
通讯作者：
Schatz, DG
影响因子：
14.9
作者：
Babarinde IA;Ma G;Li Y;Deng B;Luo Z;Liu H;Abdul MM;Ward C;Chen M;Fu X;Shi L;Duttlinger M;He J;Sun L;Li W;Zhuang Q;Tong G;Frampton J;Cazier JB;Chen J;Jauch R;Esteban MA;Hutchins AP
通讯作者：
Hutchins AP
DOI：
10.1126/science.aad5497
发表时间：
2016-03-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chuong EB;Elde NC;Feschotte C
通讯作者：
Feschotte C