NLRP3 Inflammasome: The Stormy Link Between Obesity and COVID-19.
NLRP3 Inflammasome: The Stormy Link Between Obesity and COVID-19.
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DOI：
10.3389/fimmu.2020.570251
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发表时间：
2020
影响因子：
7.3
通讯作者：
Martínez-Nava GA
中科院分区：
文献类型：
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作者：
López-Reyes A;Martinez-Armenta C;Espinosa-Velázquez R;Vázquez-Cárdenas P;Cruz-Ramos M;Palacios-Gonzalez B;Gomez-Quiroz LE;Martínez-Nava GA
在过去的40年里，由于肥胖环境的原因，世界上的几个国家都面临着严重的肥胖挑战。这种疾病具有多因素的起源，并与多种并发症有关，包括2型糖尿病、高血压、骨关节炎、代谢综合征、癌症和血脂异常。关于血脂异常，高甘油三酯血症是众所周知的NLRP3炎症体的激活剂，触发脂肪因子和细胞因子的分泌，进而诱导全身炎症状态，为感染，特别是由艾滋病毒、H1N1流感和SARS-CoV-2等病毒介导的感染提供足够的情景。SARS-CoV-2感染导致2019年冠状病毒病(新冠肺炎)，它是我们目前生活的大流行的原因。新冠肺炎会引起一种称为细胞因子释放综合症或细胞因子风暴的侵袭性免疫反应，导致多器官衰竭，在大多数情况下会导致死亡。在目前的工作中，我们旨在回顾肥胖相关的全身炎症导致更严重的新冠肺炎临床表现的分子机制。SARS-CoV-2感染可通过激活NLRP3炎症体和通过气孔释放促炎细胞因子来加重或加速肥胖者原有的全身炎症状态。
Several countries around the world have faced an important obesity challenge for the past four decades as the result of an obesogenic environment. This disease has a multifactorial origin and it is associated with multiple comorbidities including type 2 diabetes, hypertension, osteoarthritis, metabolic syndrome, cancer, and dyslipidemia. With regard to dyslipidemia, hypertriglyceridemia is a well-known activator of the NLRP3 inflammasome, triggering adipokines and cytokines secretion which in addition induce a systemic inflammatory state that provides an adequate scenario for infections, particularly those mediated by viruses such as HIV, H1N1 influenza, and SARS-CoV-2. The SARS-CoV-2 infection causes the coronavirus disease 2019 (COVID-19) and it is responsible for the pandemic that we are currently living. COVID-19 causes an aggressive immune response known as cytokine release syndrome or cytokine storm that causes multiorgan failure and in most cases leads to death. In the present work, we aimed to review the molecular mechanisms by which obesity-associated systemic inflammation could cause a more severe clinical presentation of COVID-19. The SARS-CoV-2 infection could potentiate or accelerate the pre-existing systemic inflammatory state of individuals with obesity, via the NLRP3 inflammasome activation and the release of pro-inflammatory cytokines from cells trough Gasdermin-pores commonly found in cell death by pyroptosis.