SEMIQUINONE ANION RADICALS FORMED BY THE REACTION OF QUINONES WITH GLUTATHIONE OR AMINO-ACIDS
SEMIQUINONE ANION RADICALS FORMED BY THE REACTION OF QUINONES WITH GLUTATHIONE OR AMINO-ACIDS
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DOI：
10.1016/0014-5793(86)80627-5
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发表时间：
1986-06-09
期刊：
影响因子：
3.5
通讯作者：
COHEN, GM
中科院分区：
文献类型：
--
作者：
GANT, TW;DOHERTY, MA;COHEN, GM
使用 ESR 光谱，我们表明苯醌、1,4-萘醌和 5-羟基-1,4-萘醌很容易与含硫醇的化合物（例如谷胱甘肽）反应，形成各自的半醌阴离子自由基。这些醌与氨基酸的氨基反应类似，但不太容易。醌与亲核试剂（如硫醇和胺）反应形成半醌阴离子自由基的治疗或毒理学意义仍有待评估。醌硫醇氨基酸ESRS半醌阴离子自由基
Using ESR spectroscopy, we show that benzoquinone, 1,4-naphthoquinone and 5-hydroxy-1,4-naphtho-quinone react readily with thiol containing compounds, such as glutathione, to form their respective semi-quinone anion radicals. These quinones react similarly, but less readily, with the amino group of amino acids. The therapeutic or toxicological significance of the formation of semiquinone anion radicals from the reaction of quinones with nucleophiles, such as thiols and amines, remains to be assessed.QuinoneThiolAmino acidESRSemiquinone anion radical