EFFECT OF MODERATE PHYSICAL EXERCISE ON SERUM-LIPOPROTEINS - CONTROLLED CLINICAL-TRIAL WITH SPECIAL REFERENCE TO SERUM HIGH-DENSITY LIPOPROTEINS
EFFECT OF MODERATE PHYSICAL EXERCISE ON SERUM-LIPOPROTEINS - CONTROLLED CLINICAL-TRIAL WITH SPECIAL REFERENCE TO SERUM HIGH-DENSITY LIPOPROTEINS
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DOI：
10.1161/01.cir.60.6.1220
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发表时间：
1979-01-01
期刊：
影响因子：
37.8
通讯作者：
RAURAMAA, R
中科院分区：
文献类型：
--
作者：
HUTTUNEN, JK;LANSIMIES, E;RAURAMAA, R
报告了一项关于轻度至中度体力活动对血清脂蛋白[与冠心病发展相关]的影响的对照试验。经过2次基线检查后，100名无症状中年男性被随机分配到运动组和对照组。运动组参加了4个月的运动。锻炼计划，包括每周3-4次会议。建议对照组保持之前的运动习惯。训练组的VO 2 [O2消耗量]增加证实了该计划的成功，但对照组没有。血清甘油三酯从1.54 . ±. 0.10至1.27 .+-。0.08 mmol/l（P < 0.001），高密度脂蛋白（HDL）胆固醇从1.27 . ±. 0.04至1.41 .+-。0.04运动组在试验过程中的血药浓度均低于对照组（P < 0.01）。对照组无变化。由于两组的载脂蛋白AI浓度保持不变，HDL胆固醇/载脂蛋白AI的比值仅在运动组中增加。试验期间，两组的低密度脂蛋白（LDL）胆固醇和载脂蛋白AII水平均降低。运动组中血清甘油三酯和HDL胆固醇的变化不依赖于体重减轻;在干预期间体重恒定的受试者中观察到类似的变化。
A controlled trial is reported on the effects of mild-to-moderate physical activity on serum lipoproteins [in relation to the development of coronary heart disease]. After 2 baseline examinations 100 asymptomatic middle-aged men were randomly assigned to exercise and control groups. The exercise group participated in a 4-mo. exercise program that consisted of 3-4 weekly sessions. The control group was advised to maintain their previous exercise habits. The success of the program was corroborated by the increase in VO2 [O2 consumption] in the training group, but not in the control group. Serum triglycerides decreased from 1.54 .+-. 0.10 to 1.27 .+-. 0.08 mmol/l (P < 0.001) and high-density lipoprotein (HDL) cholesterol increased from 1.27 .+-. 0.04 to 1.41 .+-. 0.04 mmol/l (P < 0.01) in the exercise group during the trial. No change was seen in the control group. As the concentration of apolipoprotein AI stayed constant in both groups, the ratio HDL cholesterol/apolipoprotein AI increased only in the exercise group. The level of low-density lipoprotein (LDL) cholesterol and apolipoprotein AII decreased in both groups during the trial. The alterations in serum triglycerides and HDL cholesterol in the exercise group were not dependent on weight reduction; similar changes were seen in subjects with constant body weight during the intervention.