Correction for respiration artefacts in myocardial perfusion SPECT is more effective when reconstructions supporting collimator detector response compensation are applied
Correction for respiration artefacts in myocardial perfusion SPECT is more effective when reconstructions supporting collimator detector response compensation are applied
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DOI：
10.1007/s12350-009-9148-z
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发表时间：
2009-12-01
影响因子：
2.4
通讯作者：
Azhari, Haim
中科院分区：
文献类型：
--
作者：
Kovalski, Gil;Keidar, Zohar;Azhari, Haim
为了评估呼吸对心肌灌注成像(MPI)SPECT的影响，采用先进的算法重建技术，对49例呼吸门控的心肌灌注成像(MPI)SPECT研究中与呼吸相关的心脏运动进行了校正。将三种重建算法：(A)滤波反投影(FBP)，(B)结合准直器响应的有序子集期望最大化(OSEM-CDR)和(C)附加衰减和散射校正的OSEM-CDR(OSEM-CDR-ACSC)应用于校正和未校正的集合，并进行定量和定性分析。校正和未校正的牛眼图的偏差分别为2%、10%和20%。在呼吸运动超过10 mm的研究中，与FBP处理相比，OSEM-CDR和OSEM-CDR-ACSC数据集的运动影响更大。OSEM-CDR和OSEM-CDR-ACSC数据校正前后的定性和定量差异明显大于FBP数据。与呼吸相关的心脏运动显著影响使用先进的高分辨率重建算法重建的MPI-SPECT，因此可能需要应用呼吸门控。
To assess the impact of respiration on myocardial perfusion imaging (MPI) SPECT processed with advanced algorithmic reconstructions.SPECT studies obtained from a phantom simulation and 49 respiratory-gated, one-day Tc-99m-sestamibi scans were corrected for respiratory-related cardiac movement. Three types of reconstruction algorithms: (a) filtered back projection (FBP), (b) ordered subset expectation maximization in which collimator detector response was incorporated (OSEM-CDR), and (c) OSEM-CDR with additional attenuation and scatter corrections (OSEM-CDR-ACSC) were applied to the corrected and uncorrected sets and analyzed quantitatively and qualitatively.A discrepancy between the corrected and uncorrected bull's eye maps a parts per thousand yen10% was found in 2%, 10%, and 20% of the FBP, OSEM-CDR, and OSEM-CDR-ACSC scans, respectively. In studies with more than 10-mm respiratory motion, the effect of motion was greater in OSEM-CDR and OSEM-CDR-ACSC datasets as compared to FBP processing. Qualitative and quantitative differences between corrected and uncorrected sets were significantly larger in OSEM-CDR and OSEM-CDR-ACSC data than in those of FBP data.Respiratory-related cardiac motion significantly affects MPI-SPECT reconstructed with advanced high-resolution reconstruction algorithms such as OSEM-CDR and OSEM-CDR-ACSC and thus may justifies the application of respiratory gating.