Clinical, cognitive and anatomical evolution from nonfluent progressive aphasia to corticobasal syndrome: A case report
Clinical, cognitive and anatomical evolution from nonfluent progressive aphasia to corticobasal syndrome: A case report
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DOI：
10.1080/13554790490894011
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发表时间：
2004-12-01
期刊：
影响因子：
0.8
通讯作者：
Miller, BL
中科院分区：
文献类型：
--
作者：
Gorno-Tempini, ML;Murray, RC;Miller, BL
最近的临床和病理研究表明，额颞叶变性（FTLD）和皮质基底综合征（CBS）表现出临床和病理上的重叠。我们报告了一名56岁女性AS的四年纵向临床、认知和解剖学数据，她的临床表现从FTLD发展到CBS。前三年，AS表现出进行性言语和语言障碍，与诊断为FTLD的非流利性失语症变体相一致。在第四年，即首次出现症状10年后，AS出现了CBS的典型临床症状，包括异肢现象和肌张力障碍。基于体素的形态测量（VBM）应用于AS的四次年度扫描显示萎缩的进展，从额后回下到左脑岛，最后到中叶[额叶]。本病例显示了FTLD和CBS的临床重叠，并表明两者可以出现在同一患者的不同阶段，与解剖损伤的进展有关。
Recent clinical and pathological studies have suggested that frontotemporal lobar degeneration (FTLD) and corticobasal syndrome (CBS) show clinical and pathological overlap. We present four years of longitudinal clinical, cognitive and anatomical data in the case of a 56-year-old woman, AS, whose clinical picture evolved from FTLD to CBS. For the first three years, AS showed a progressive speech and language disorder compatible with a diagnosis of the nonfluent aphasia variant of FTLD. At year four, 10 years after her first symptom, AS developed the classical clinical signs of CBS, including alien limb phenomenon and dystonia. Voxel-based morphometry (VBM) applied to AS's four annual scans showed progression of atrophy from the inferior posterior frontal gyrus, to the left insula and finally to the media[ frontal lobe. This case demonstrates the clinical overlap between FTLD and CBS and shows that the two can appear in the same patient at different stages of the disease in relation to the progression of anatomical damage.