Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice
Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice
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DOI：
10.1111/j.1365-2249.2006.03044.x
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发表时间：
2006-04-01
影响因子：
4.6
通讯作者：
Blumberg, RS
中科院分区：
文献类型：
--
作者：
Utku, N;Heinemann, T;Blumberg, RS
TIRC 7是在T和B淋巴细胞中表达并负调节其功能的细胞表面分子。抗TIRC 7特异性单克隆抗体（mAb）抑制T细胞对回忆抗原的记忆应答。类风湿性关节炎（RA）患者和胶原诱导性关节炎（CIA）小鼠关节组织淋巴细胞上TIRC 7的上调表明TIRC 7是促进抗炎反应的新靶点。抗TIRC 7 mAb给药显著抑制CIA的诱导和进展以及抗胶原IgG 1和IgG 2a抗体应答。抗TIRC 7 mAb和可溶性TNF-α受体的联合治疗显示出比单一化合物对CIA的抑制作用增加。结果证明了用mAb靶向TIRC 7在与过度的T和B细胞应答相关的疾病中的治疗潜力。
TIRC7 is a cell surface molecule which is expressed in T and B lymphocytes and negatively regulates their function. Anti-TIRC7 specific monoclonal antibody (mAb) inhibited T cell memory response to recall antigens. Up-regulation of TIRC7 on lymphocytes from joint tissue of patients with Rheumatoid Arthritis (RA) and mice with collagen induced arthritis (CIA) suggested TIRC7 as a novel target to promote anti-inflammatory reaction. Anti-TIRC7 mAb administration significantly inhibited the induction and progression of CIA and the anti-collagen IgG1 and IgG2a antibody response. Combination therapy of anti-TIRC7 mAb and soluble TNF-alpha receptor demonstrated an increased inhibitory effect over the single compounds on CIA. The results demonstrate the therapeutic potential of TIRC7 targeting with mAb in diseases associated with exaggerated T and B cell responses.