Grey matter connectivity within and between auditory, language and visual systems in prelingually deaf adolescents.
Grey matter connectivity within and between auditory, language and visual systems in prelingually deaf adolescents.
复制标题
语前聋青少年听觉、语言和视觉系统内部和之间的灰质连接。
DOI：
10.3233/rnn-140437
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发表时间：
2015
影响因子：
2.8
通讯作者：
He H
中科院分区：
文献类型：
--
作者：
Li W;Li J;Wang Z;Li Y;Liu Z;Yan F;Xian J;He H
目的：先前的研究表明，早期听觉丧失后，大脑会发生重组。然而，语言前期失聪青少年大脑灰质连通性的变化尚未被研究。在本研究中，我们旨在研究语言前期失聪青少年听觉、语言和视觉系统内部和之间灰质连通性的变化。方法：我们招募了16名语前聋青少年和16名年龄性别匹配的正常对照，并从14个涉及听觉、语言和视觉加工的感兴趣区中提取灰质体积作为结构特征，以研究听觉、语言和视觉系统内部和之间灰质连通性的变化。稀疏逆协方差估计(SICE)用于构建这些脑区之间的灰质连通性。结果：语言前期失聪青少年的听觉和视觉系统中的灰质连接性较弱，语言和视觉系统之间的连接性下降。值得注意的是，在语言前期聋人青少年中，发现听觉和视觉系统之间的大脑连接显著增加。结论：我们的结果表明，在语言前期失聪的青少年中，听觉输入被剥夺后，尤其是在听觉和视觉系统之间，存在“跨模式”可塑性。此外，听觉剥夺和视觉缺陷可能影响语前聋青少年语言和视觉系统的连接模式。
Purpose: Previous studies have shown brain reorganizations after early deprivation of auditory sensory. However, changes of grey matter connectivity have not been investigated in prelingually deaf adolescents yet. In the present study, we aimed to investigate changes of grey matter connectivity within and between auditory, language and visual systems in prelingually deaf adolescents. Methods: We recruited 16 prelingually deaf adolescents and 16 age-and gender-matched normal controls, and extracted the grey matter volume as the structural characteristic from 14 regions of interest involved in auditory, language or visual processing to investigate the changes of grey matter connectivity within and between auditory, language and visual systems. Sparse inverse covariance estimation (SICE) was utilized to construct grey matter connectivity between these brain regions. Results: The results show that prelingually deaf adolescents present weaker grey matter connectivity within auditory and visual systems, and connectivity between language and visual systems declined. Notably, significantly increased brain connectivity was found between auditory and visual systems in prelingually deaf adolescents. Conclusions: Our results indicate “cross-modal” plasticity after deprivation of the auditory input in prelingually deaf adolescents, especially between auditory and visual systems. Besides, auditory deprivation and visual deficits might affect the connectivity pattern within language and visual systems in prelingually deaf adolescents.