The Role of Alternative Splicing in Cancer: Regulatory Mechanism, Therapeutic Strategy, and Bioinformatics Application
The Role of Alternative Splicing in Cancer: Regulatory Mechanism, Therapeutic Strategy, and Bioinformatics Application
复制标题
选择性剪接在癌症中的作用：调节机制、治疗策略和生物信息学应用。
DOI：
10.1089/dna.2022.0322
复制
发表时间：
2022-08-10
影响因子：
3.1
通讯作者：
Pei，Dong-Sheng
中科院分区：
文献类型：
--
作者：
Pan，Yao-Jie;Liu，Bo-wen;Pei，Dong-Sheng
选择性剪接（AS）可以产生不同的转录本和随后的异构体，发挥不同的功能，从相同的前mRNA。最近，越来越多的研究已经出现，揭示了AS和癌症之间的联系。在这篇综述中，我们整理了与癌症进展密切相关的AS事件，并提出了基于AS的癌症治疗的有希望的治疗方法。获得增殖能力、获得侵袭性、获得血管生成特征、改变代谢能力和获得免疫逃逸倾向都是参与生物过程的剪接事件。剪接体靶向技术和反义寡核苷酸技术是两种有望用于肿瘤治疗的新策略。此外，为了更好地预测和阐明其中的调控途径，还对基于AS的生物信息学应用进行了总结。我们的目标是更好地了解与癌症生物学相关的复杂AS事件，并揭示AS是未来癌症治疗的一个有希望的靶点。
Alternative splicing (AS) can generate distinct transcripts and subsequent isoforms that play differential functions from the same pre-mRNA. Recently, increasing numbers of studies have emerged, unmasking the association between AS and cancer. In this review, we arranged AS events that are closely related to cancer progression and presented promising treatments based on AS for cancer therapy. Obtaining proliferative capacity, acquiring invasive properties, gaining angiogenic features, shifting metabolic ability, and getting immune escape inclination are all splicing events involved in biological processes. Spliceosome-targeted and antisense oligonucleotide technologies are two novel strategies that are hopeful in tumor therapy. In addition, bioinformatics applications based on AS were summarized for better prediction and elucidation of regulatory routines mingled in. Together, we aimed to provide a better understanding of complicated AS events associated with cancer biology and reveal AS a promising target of cancer treatment in the future.