The medical-irradiation characteristics for neutron capture therapy at the Heavy Water Neutron Irradiation Facility of Kyoto University Research Reactor
The medical-irradiation characteristics for neutron capture therapy at the Heavy Water Neutron Irradiation Facility of Kyoto University Research Reactor
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DOI：
10.1118/1.1509444
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发表时间：
2002-10-01
期刊：
影响因子：
3.8
通讯作者：
Kobayashi, T
中科院分区：
文献类型：
--
作者：
Sakurai, Y;Kobayashi, T
在京都大学研究堆的重水中子辐照设施中，除了热中子辐照之外，还可以进行热中子和超热中子的混合辐照以及超热中子的单独辐照，并且在1996年更新后，该设施的中子捕获治疗（NCT）变得更加灵活。从实验和计算两个方面对热中子、混合中子和超热中子标准照射模式下NCT临床照射深度剂量分布进行了估算。假设肿瘤部分中的B-10浓度为40 ppm，肿瘤与正常组织的比率为3.5，对于相应的标准照射模式，估计的优势深度为5.4、6.0和8.0。据证实，各种照射条件可以选择根据目标体积条件，如大小，深度等。对患者的辐射屏蔽，证实了新的临床准直器有效地减少了全身照射，与旧的相比。(C)2002年美国医学物理学家协会。
At the Heavy Water Neutron Irradiation Facility of the Kyoto University Research Reactor, the mix irradiation of thermal and epi-thermal neutrons, and the solo irradiation of epi-thermal neutrons are available additionally to the thermal neutron irradiation, and then the neutron capture therapy (NCT) at this facility became more flexible, after the update in 1996. The estimation of the depth dose distributions in NCT clinical irradiation, were performed for the standard irradiation modes of thermal, mixed and epi-thermal neutrons, from the both sides of experiment and calculation. On the assumption that the B-10 concentration in tumor part was 40 ppm and the ratio of tumor to normal tissue was 3.5, the advantage depth were estimated to 5.4, 6.0, and 8.0, for the respective standard irradiation modes. It was confirmed that the various irradiation conditions can be selected according to the target-volume conditions, such as size, depth, etc. Besides, in the viewpoint of the. radiation shielding for patient, it was confirmed that the whole-body exposure is effectively reduced by the new clinical collimators, compared with the old one. (C) 2002 American Association of Physicists in Medicine.