Sorting nexins provide diversity for retromer-dependent trafficking events.

Sorting nexins provide diversity for retromer-dependent trafficking events.
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DOI:
10.1038/ncb2374
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发表时间:
2011-12-22
影响因子:
21.3
通讯作者:
--
中科院分区:
生物学1区
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--
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分拣连接素是一个进化上保守的磷脂酰肌醇结合蛋白大家族,在通过膜迷宫(即内体网络)协调货物分拣过程中发挥重要作用。一组古老的含有Nexin的复合体是逆聚体。在这里,我们讨论逆转录复合体如何调节内体分选,并描述这如何产生令人兴奋的新见解,以了解内体分选在发育和正常组织动态平衡中所起的核心作用。
Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that play fundamental roles in orchestrating the process of cargo sorting through the membranous maze that is the endosomal network. One ancient group of sorting nexin-containing complexes is the retromers. Here we discuss how retromer complexes regulate endosomal sorting, and describe how this is generating exciting new insight into the central role played by endosomal sorting in development, and normal tissue homeostasis.
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