Sources of phytoestrogen exposure among non-Asian women in California, USA
Sources of phytoestrogen exposure among non-Asian women in California, USA
复制标题
DOI：
10.1023/a:1008968003575
复制
发表时间：
2000-04-01
影响因子：
2.3
通讯作者：
Koo, J
中科院分区：
文献类型：
--
作者：
Horn-Ross, PL;Lee, M;Koo, J
目的：我们最近描述了一个用于评估流行病学研究中植物雌激素暴露的综合数据库的开发[b]。本文介绍了该数据库的首次应用以及非亚洲女性植物雌激素消费的主要来源。方法：447名随机选择的非裔美国人、拉丁裔和白人女性，年龄50 - 79岁，居住在加州旧金山湾区，作为对照参与了一项正在进行的基于人群的乳腺癌病例对照研究，纳入本分析。通过将新数据库中的值与食物频率调查问卷中报告的食物消费量相结合，确定了每位妇女七种植物雌激素化合物中每种化合物的平均每日消费量。结果：非亚洲海湾地区饮食中的植物雌激素似乎主要来自：(1)传统的大豆食品（如豆腐和豆浆）；(2)“隐藏”的大豆来源（如含有添加大豆蛋白的浓缩食品，或豆粉，如许多品牌的甜甜圈和白面包）；(3)每100克只含有低至中等含量植物雌激素但经常食用的各种食物（如咖啡和橙汁）。结论：由于缺乏对各种食品中各种植物雌激素的全面评估，流行病学研究可能受到未测量植物雌激素暴露来源的不受控制的混淆的影响，可能导致对效果的估计有偏倚和对研究结果的误解。
Objective: We recently described the development of a comprehensive database for assessing phytoestrogen exposure in epidemiologic studies [1]. This paper describes the first application of this database and the primary sources of phytoestrogen consumption in non-Asian women.Methods: Four hundred and forty-seven randomly selected African-American, Latina, and white women, ages 50 79 years, residing in California's San Francisco Bay Area and participating as controls in an ongoing population-based case-control study of breast cancer, were included in the present analysis. Average daily consumption of each of seven phytoestrogenic compounds was determined for each woman by combining the values from the new database with food consumption reported on a food-frequency questionnaire.Results: Phytoestrogens in the non-Asian Bay Area diet appear to come primarily from: (1) traditional soy-based foods (e.g. tofu and soy milk); (2) "hidden" sources of soy (e.g. foods containing added soy protein is concentrate, or soy flour, e.g. many brands of doughnuts and white bread); and (3) a variety of foods which contain only low to moderate amounts of phytoestrogens per 100 grams but which are frequently consumed (e.g. coffee and orange juice).Conclusions: In the absence of a comprehensive assessment of various phytoestrogens in a wide variety of foods, epidemiologic studies could suffer from the effects of uncontrolled confounding by unmeasured sources of phytoestrogen exposure potentially leading to biased estimates of effect and misinterpretation of findings.