HPV genotypic spectrum in Jilin province, China, where non-vaccine-covered HPV53 and 51 are prevalent, exhibits a bimodal age-specific pattern
HPV genotypic spectrum in Jilin province, China, where non-vaccine-covered HPV53 and 51 are prevalent, exhibits a bimodal age-specific pattern
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DOI：
10.1371/journal.pone.0230640
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发表时间：
2020-03-24
期刊：
影响因子：
3.7
通讯作者：
Jiang, Yanfang
中科院分区：
文献类型：
--
作者：
Hao, Sijia;Wang, Chunyan;Jiang, Yanfang
研究背景人乳头瘤病毒（Human papillomavirus，HPV）是最常见的性传播疾病，与一系列其他疾病有关。高危型HPV（high-risk HPV，HR-HPV）的持续感染被认为是宫颈癌的致病因素，与非宫颈癌的发生密切相关。方法2017年10月至2019年9月，收集吉林省21,282例宫颈癌患者（男性634例，女性20,648例），采用HPV基因分型板进行HPV感染检测。年龄相关的HPV感染率和发病率的HPV为基础的疾病和HPV感染率与特定diseases.ResultsA共7095（34.4%）阳性的HPV感染的20648名妇女和164（25.8%）阳性的634名男子进行了分析。女性HPV感染呈双峰型，年轻组为一高峰，老年组为第二高峰，且随着宫颈病变程度的加重而加重。女性中HPV 16（7.8%）、HPV 52（5.8%）、HPV 58（5.0%）、HPV 53（3.4%）和HPV 51（3.0%）是最常见的基因型;男性中HPV 6（6.0%）、HPV 11（5.7%）、HPV 16（3.6%）、HPV 18（2.7%）和HPV 51（3.0%）是最常见的基因型。吉林省HPV感染和宫颈癌中HPV 53和51型的检出率分别为6.3%和8.9%。此外，45.5%的女性和28.6%的男性生殖器疣感染HR-HPV genotype.ConclusionThe HPV基因型谱在吉林省，其中非疫苗覆盖的HPV 53和51流行，表现出年龄和宫颈病变的特定模式，这为HPV疫苗接种和宫颈癌筛查提供了指导。男性HPV感染和良性增生性病变不容忽视。
BackgroundHuman papillomavirus (HPV), the most common sexually transmitted disease, is involved in a series of other diseases. The persistent infection of high-risk HPVs (HR-HPVs) is considered to be the causative agent of cervical cancer, and it is related to noncervical cancers. The present study aims to estimate the HPV prevalence and genotype distribution in Jilin province, China, to guide HPV-related cervical cancer screening and HPV vaccination.MethodsFrom October 2017 to September 2019, 21,282 samples (634 male and 20,648 female) were collected for HPV infection detection using an HPV genotyping panel. The age-related HPV prevalence and morbidity of HPV-based disease and HPV prevalence associated with specific diseases were analyzed.ResultsA total of 7095 (34.4%) positive for HPV infection of 20648 women, and 164 (25.8%) positive of 634 men. The HPV prevalence among women exhibited a bimodal pattern, with a peak in young group and a second peak in old group, with increased severity of cervical lesions. HPV16 (7.8%), HPV52 (5.8%), HPV58 (5.0%), HPV53 (3.4%), and HPV51 (3.0%) were the most prevalent genotypes among women, and HPV6 (6.0%), HPV11 (5.7%), HPV16 (3.6%), HPV18 (2.7%), and HPV51 (3.0%) were prevalent among men. Non-vaccine-covered HPV53 and 51 were found in 6.3% of HPV infection and 8.9% of cervical cancer in Jilin province. Furthermore, 45.5% of females and 28.6% of males with genital warts were infected with HR-HPV genotypes.ConclusionThe HPV genotypic spectrum in Jilin province, where non-vaccine-covered HPV53 and 51 were prevalent, exhibited an age- and cervical lesion-specific pattern, which provides guidance for HPV vaccination and cervical cancer screening. HPV infection in men and benign hyper-proliferative lesions should not be neglected.