Quantification of physiological and hemodynamic indices using T1 dynamic contrast-enhanced MRI in intracranial mass lesions
Quantification of physiological and hemodynamic indices using T1 dynamic contrast-enhanced MRI in intracranial mass lesions
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DOI：
10.1002/jmri.21080
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发表时间：
2007-10-01
影响因子：
4.4
通讯作者：
Gupta, Rakesh K.
中科院分区：
文献类型：
--
作者：
Singh, Anup;Haris, Mohammad;Gupta, Rakesh K.
Purpose: To estimate precontrast tissue parameter (T-10) using fast spin echo (FSE) and to quantify physiological and hemodynamic parameters with leakage correction using T-1-weighted dynamic contrast enhanced (DCE) perfusion imaging.Materials and Methods: Voxel-wise T-10 computation was performed followed by the analysis of T-1-weighted DCE perfusion data for the conversion of signal intensity time curve to concentration time curve, estimation of hemodynamic and physiological perfusion indices, and a method for leak age correction. Validations of accuracy of the computations have also been carried out.Results: The computed T-10 and hemodynamic perfusion indices in normal white and gray matter were in good agreement with the literature values. Physiological perfusion indices in these regions were found negligible, validating computations. Cerebral blood volume (CBVcorrected), while CBVuncorrected (lesion) shows linear increase over time.Conclusion: T-1-weighted DCE perfusion data along with FSE-based T-1 estimation can be used for an accurate estimation of hemodynamic and physiological perfusion indices.
