Visceral afferent bias on cortical processing: role of adrenergic afferents to the basal forebrain cholinergic system.
Visceral afferent bias on cortical processing: role of adrenergic afferents to the basal forebrain cholinergic system.
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皮质处理的内脏传入偏差：肾上腺素能传入对基底前脑胆碱能系统的作用。
DOI：
10.1037/0735-7044.118.6.1455
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Berntson,GaryG
中科院分区：
文献类型：
--
作者：
Knox,Dayan;Sarter,Martin;Berntson,GaryG
Intraperitoneal epinephrine enhances the cerebral auditory evoked potential (AEP), an effect that is dependent on the basal forebrain cortical cholinergic system. The present study examined the hypothesis that ascending noradrenergic projections from brainstem autonomic substrates to the basal forebrain cholinergic system represent an essential component of the ascending pathway mediating this effect of epinephrine. Epinephrine again enhanced the AEP in rats, and this effect was attenuated by infusion of the selective α1 adrenergic antagonist terazosin into the basal forebrain. Moreover, infusions of the selective α1 adrenergic agonist phenylephrine into the basal forebrain mimicked the priming effects of epinephrine. Results support the hypothesis that noradrenergic afferents to the basal forebrain cholinergic system represent a component of an ascending visceral afferent system.
