HERPES-TYPE VIRUS AND CHROMOSOME MARKER IN NORMAL LEUKOCYTES AFTER GROWTH WITH IRRADIATED BURKITT CELLS
HERPES-TYPE VIRUS AND CHROMOSOME MARKER IN NORMAL LEUKOCYTES AFTER GROWTH WITH IRRADIATED BURKITT CELLS
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DOI：
10.1126/science.157.3792.1064
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发表时间：
1967-01-01
期刊：
影响因子：
56.9
通讯作者：
HENLE, G
中科院分区：
文献类型：
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作者：
HENLE, W;DIEHL, V;HENLE, G
对来自伯基特淋巴瘤男性患者并携带疱疹型病毒颗粒的培养细胞进行致死性辐照。这些辐射细胞在混合培养后2至4周内诱导女婴的正常外周血白细胞生长。不含该试剂的细胞系不能刺激生长。如果单独培养任何一种细胞，在实验条件下都不能存活。在获得的所有雌性细胞培养物中均发现了先前在培养的伯基特细胞中描述的疱疹型病毒抗原和C组染色体标记。
Cultured cells derived from male patients with Burkitt''s lymphoma and harboring herpes-types virus particles were lethally irradiated. These irradiated cells induced normal peripheral leukocytes of female infants to grow within 2 to 4 weeks after mixed cultivation. Cells of a line free of this agent failed to stimulate growth. If either type of cell was cultured separately, it did not survive under the experimental conditions. Herpes-type viral antigen and C-group chromosomal marker previously described in cultured Burkitt cells were found in all of the female cell cultures that were obtained.