Functional connectivity of the angular gyrus in normal reading and dyslexia
Functional connectivity of the angular gyrus in normal reading and dyslexia
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DOI：
10.1073/pnas.95.15.8939
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发表时间：
1998-07-21
影响因子：
11.1
通讯作者：
Donohue, BC
中科院分区：
文献类型：
--
作者：
Horwitz, B;Rumsey, JM;Donohue, BC
基于对获得性失读症患者的研究，经典的阅读神经模型假设左半球角回与枕叶和颞叶的视觉关联区域之间存在功能联系。角回也被认为与后部语言区域（如韦尼克区）具有功能联系，因为它被认为参与将视觉呈现的输入映射到语言表征。使用正电子发射断层扫描，我们证明了在正常男性中，左角回的区域脑血流量显示出强烈的任务内、跨对象相关性。单字阅读时枕叶外和颞叶区域的脑血流。相比之下，在患有持续性发展性阅读障碍的男性中，左角回在功能上与这些区域断开，这表明在许多获得性失读症中，左角回与其他大脑区域（正常的大脑阅读网络的一部分）的解剖断开反映在发展性阅读障碍中的功能断开。
The classic neurologic model for reading, based on studies of patients with acquired alexia, hypothesizes functional linkages between the angular gyrus in the left hemisphere and visual association areas in the occipital and temporal lobes, The angular gyrus also is thought to have functional links with posterior language areas (e,g,, Wernicke's area), because it is presumed to be involved in mapping visually presented inputs onto linguistic representations. Using positron emission tomography,we demonstrate in normal men that regional cerebral blood flow in the left angular gyrus shows strong within-task, across-subjects correlations (i,e., functional connectivity) with regional cerebral blood flow in extrastriate occipital and temporal lobe regions during single word reading. In contrast, the left angular gyrus is functionally disconnected from these regions in men with persistent developmental dyslexia, suggesting that the anatomical disconnection of the left angular gyrus from other brain regions that are part of the "normal" brain reading network in many cases of acquired alexia is mirrored by its functional disconnection in developmental dyslexia.